Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)aryl Halides with 2-Chloro-1,1-difluoroethane: Facile Access to 2,2-Difluoroethylated Aromatics

A mild and efficient nickel-catalyzed 2,2-difluoroethylation of (hetero)aryl halides with readily available 2-chloro-1,1-difluoroethane has been developed. The reductive cross-coupling reaction is synthetically simple and exhibits good functional group tolerance. This approach provides a facile access to synthesize 2,2-difluoroethylated molecules for drug discovery.

Automated summary

A mild and efficient method for the synthesis of 2,2-difluoroethylated (hetero)aryl halides using readily available 2-chloro-1,1-difluoroethane has been developed. The reductive cross-coupling reaction is synthetically simple and exhibits good functional group tolerance. This approach provides a facile access to synthesize 2,2-difluoroethylated molecules for drug discovery.