Sperm-oviduct interactions: Key factors for sperm survival and maintenance of sperm fertilizing capacity

Background: Although millions or even billions of sperm are deposited in the female genital tract, only very few sperm reach the oocyte, and only one single spermatozoon will successfully fertilize. During the journey of the sperm within the female genital tract, the interactions between spermatozoa and fallopian tube are critical for sperm selection, sperm survival, and maintenance of sperm fertilizing capacity. Results: This review will provide a comprehensive overview of the latest findings regarding sperm transport and behavior of sperm within the oviduct, sperm selection in the oviduct, the formation of the sperm reservoir, and the release of sperm in the presence of the oocyte. It will primarily focus on recent novel insights on sperm-oviduct interactions, which have been obtained by cutting-edge technologies under in vivo or near in vivo conditions. Conclusions: The comprehensive analysis of the findings to date will elucidate the complex molecular changes in the tubal epithelium, which are induced by the presence of the sperm and will highlight how the epithelial cells of this organ affect transport, behavior, and function of sperm. This knowledge is essential for scientists and clinicians involved in assisted reproductive technologies.

Automated summary

This review provides the latest research progress on the transport and behavior of sperm within the oviduct, sperm selection, formation of the sperm reservoir, and sperm release in the presence of oocytes. It focuses on the novel insights obtained through cutting-edge technologies in vivo or near in vivo conditions regarding the interactions between sperm and the oviduct. This knowledge is crucial for scientists and clinicians in the field of assisted reproductive technologies.