期刊
CANCER LETTERS
卷 361, 期 1, 页码 13-21出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.03.002
关键词
Long noncoding RNAs; Colorectal cancer (CRC); Tumorigenesis; Therapeutic targets
类别
资金
- Natural Science Foundation of Heilongjiang Province for youth [QC2013C089]
- Science and Technology Research Project of Education Department in Heilongjiang Province [12531226]
- Postdoctoral Foundation of Heilongjiang Province [LBH-Z12172/LBH-TZ0415]
- Research Foundation for the Doctoral Program of Higher Education [20122307110002]
- Science and Technology Project of Heilongjiang Province [2013G1002]
- Harbin and Yu weihan academician fund for distinguished young Scholars of Harbin medical university [2014RFXGJ053]
Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These IncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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