期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 40, 页码 20858-20868出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R116.742023
关键词
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资金
- National Institutes of Health [GM042569, GM118157]
- Pew Latin American Fellows Program in the Biomedical Sciences
Among the biologically required first row, late d-block metals from Mn-II to Zn-II, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The vertebrate innate immune system uses several strategies to exploit this Achilles heel of microbial physiology, but bacterial evolution has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mechanisms that pathogens use to win the fight over zinc and thrive in an otherwise hostile environment.
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