相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Indoxyl and p-cresol sulfate binding with human serum albumin
Shuhui Li et al.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)
The Prescription of Drugs That Inhibit Organic Anion Transporters 1 or 3 Is Associated with the Plasma Accumulation of Uremic Toxins in Kidney Transplant Recipients
Camille Andre et al.
TOXINS (2022)
The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease
Chao Han et al.
FRONTIERS IN MEDICINE (2022)
Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors
Camille Andre et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3
Ling Zou et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2021)
Inhibitory effects of vandetanib on creatinine transport via renal organic cation transporter OCT2
Yuko Tanihara et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)
Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease
Griet Glorieux et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)
The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients
Kenshiro Hirata et al.
TOXINS (2021)
Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3
Jeffry C. Granados et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease
Anisha K. Nigam et al.
PHARMACEUTICS (2021)
Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2
Tetsuya Taniguchi et al.
SCIENTIFIC REPORTS (2021)
The Impact of CKD on Uremic Toxins and Gut Microbiota
Jacek Rysz et al.
TOXINS (2021)
Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System
Carlos Alexandre Falconi et al.
FRONTIERS IN PHYSIOLOGY (2021)
Uremic Toxins in Organ Crosstalk
Jerome Lowenstein et al.
FRONTIERS IN MEDICINE (2021)
In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs
Blessy George et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Linoleic acid-modified liposomes for the removal of protein-bound toxins: An in vitro study
Yue Shen et al.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2021)
Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
Daniel Y. Li et al.
JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)
Effects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin
Shu-Shang Luo et al.
XENOBIOTICA (2020)
Difference in Profiles of the Gut-Derived Tryptophan Metabolite Indole Acetic Acid between Transplanted and Non-Transplanted Patients with Chronic Kidney Disease
Sophie Liabeuf et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome
Maaike K. van Gelder et al.
TOXINS (2020)
Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) andl-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells
Emir Taghikhani et al.
AMINO ACIDS (2020)
P-cresyl sulfate causes mitochondrial hyperfusion in H9C2 cardiomyoblasts
Tien-Hung Huang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
How do Uremic Toxins Affect the Endothelium?
Regiane Stafim da Cunha et al.
TOXINS (2020)
Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions
Daniel Scotcher et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2020)
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease
Kevin T. Bush et al.
JCI INSIGHT (2020)
Enhanced Removal of Protein-Bound Uremic Toxins Using Displacers Road to Success?
Wim Van Biesen et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)
Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor
Magdalena Madero et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)
Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects
Tomohisa Nakada et al.
DRUG METABOLISM AND PHARMACOKINETICS (2019)
The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine
Emir Taghikhani et al.
PLOS ONE (2019)
Adsorption of Protein-Bound Uremic Toxins Using Activated Carbon through Direct Hemoperfusion in vitro
Suguru Yamamoto et al.
BLOOD PURIFICATION (2019)
Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages
Hee Young Kim et al.
FASEB JOURNAL (2019)
Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne's Thread
Anila Duni et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
REMOVAL OF PROTEIN-BOUND UREMIC TOXINS BY LIPOSOME-SUPPORTED PERITONEAL DIALYSIS
Yuanyuan Shi et al.
PERITONEAL DIALYSIS INTERNATIONAL (2019)
Effect of Ionic Strength, pH and Chemical Displacers on the Percentage Protein Binding of Protein-Bound Uremic Toxins
Yuanyuan Shi et al.
BLOOD PURIFICATION (2019)
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease
Toshiaki Nakano et al.
CIRCULATION (2019)
Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium
Birgit Deutsch et al.
MOLECULAR PHARMACEUTICS (2019)
Strategies for Phosphate Control in Patients With CKD
Fellype Carvalho Barreto et al.
KIDNEY INTERNATIONAL REPORTS (2019)
The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease
Sanjay K. Nigam
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)
Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells
Hisakazu Komori et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)
Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease
Kaori Morimoto et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2018)
Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease
Laetitia Dou et al.
KIDNEY INTERNATIONAL (2018)
Aryl hydrocarbon receptor and intestinal immunity
Bruno Lamas et al.
MUCOSAL IMMUNOLOGY (2018)
Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells
Takeo Edamatsu et al.
PLOS ONE (2018)
ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study
Chung-Jen Chen et al.
SCIENTIFIC REPORTS (2018)
Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1
Saki Omote et al.
SCIENTIFIC REPORTS (2018)
Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
T. Takada et al.
SCIENTIFIC REPORTS (2018)
Is 3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) a Clinically Relevant Uremic Toxin in Haemodialysis Patients?
Mathilde Luce et al.
TOXINS (2018)
Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)
A. Gessner et al.
SCIENTIFIC REPORTS (2018)
Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome
Suree Lekawanvijit
TOXINS (2018)
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters
Wendy A. Teft et al.
MOLECULAR PHARMACEUTICS (2017)
Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
Xinmin S. Li et al.
EUROPEAN HEART JOURNAL (2017)
The Effect of Uremic Solutes on the Organic Cation Transporter 2
Kit Wun Kathy Cheung et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide
Takeshi Miyake et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression
Giane Favretto et al.
JOURNAL OF VASCULAR RESEARCH (2017)
Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease
Huichang Gao et al.
LIFE SCIENCES (2017)
Furan fatty acids - Beneficial or harmful to health?
Long Xu et al.
PROGRESS IN LIPID RESEARCH (2017)
Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies
Ricardo J. Ferreira et al.
SCIENTIFIC REPORTS (2017)
Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
Wei Wu et al.
SCIENTIFIC REPORTS (2017)
Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients
Tariq Shafi et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2017)
Inhibition of Methotrexate Uptake via Organic Anion Transporters OAT1 and OAT3 by Glucuronides of Nonsteroidal Anti-inflammatory Drugs
Masahiro Iwaki et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2017)
Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden
Jason R. Stubbs et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)
Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure
Ken-ichi Fujita et al.
PHARMACEUTICAL RESEARCH (2016)
Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine
Anne T. Nies et al.
ARCHIVES OF TOXICOLOGY (2016)
The type III transporters (PiT-1 and PiT-2) are the major sodium-dependent phosphate transporters in the mice and human brains
Masatoshi Inden et al.
BRAIN RESEARCH (2016)
Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease
Michito Nagura et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2016)
Reconsidering the Lack of Urea Toxicity in Dialysis Patients
Ziad A. Massy et al.
SEMINARS IN DIALYSIS (2016)
CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?
Laetitia Koppe et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1
Yuki Enoki et al.
SCIENTIFIC REPORTS (2016)
Improved dialytic removal of protein-bound uraemic toxins with use of albumin binding competitors: an in vitro human whole blood study
Xia Tao et al.
SCIENTIFIC REPORTS (2016)
Bioengineered kidney tubules efficiently excrete uremic toxins
J. Jansen et al.
SCIENTIFIC REPORTS (2016)
Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4
Atsushi Kawase et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approachs
Henry C. Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron
Davorka Breljak et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)
Release of Uremic Retention Solutes from Protein Binding by Hypertonic Predilution Hemodiafiltration
Falko Boehringer et al.
ASAIO JOURNAL (2015)
Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells
Nicholas W. Chavkin et al.
EXPERIMENTAL CELL RESEARCH (2015)
Hyperphosphatemia, Phosphoprotein Phosphatases, and Microparticle Release in Vascular Endothelial Cells
Nima Abbasian et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy
Ke Yang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
THE ORGANIC ANION TRANSPORTER (OAT) FAMILY: A SYSTEMS BIOLOGY PERSPECTIVE
Sanjay K. Nigam et al.
PHYSIOLOGICAL REVIEWS (2015)
Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology
Henricus A. M. Mutsaers et al.
TOXICOLOGY IN VITRO (2015)
p-Cresyl Sulfate Aggravates Cardiac Dysfunction Associated With Chronic Kidney Disease by Enhancing Apoptosis of Cardiomyocytes
Hui Han et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2015)
In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells
Yang Lu et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)
The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid
Laetitia Dou et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates
Kristina Hacker et al.
PLOS ONE (2015)
Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange
Adam G. Hotchkiss et al.
DRUG METABOLISM AND DISPOSITION (2015)
Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression
Hong Shen et al.
DRUG METABOLISM AND DISPOSITION (2015)
Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics
Li Wang et al.
DRUG METABOLISM AND DISPOSITION (2015)
p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress
Hiroshi Watanabe et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2015)
The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction
Kacey J. Prentice et al.
CELL METABOLISM (2014)
Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate, a uremic toxin
Hiroshi Watanabe et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2014)
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans
Kazuya Maeda et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review
Raymond Vanholder et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
Eve-Irene Lepist et al.
KIDNEY INTERNATIONAL (2014)
Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans
Ken-ichi Fujita et al.
PHARMACEUTICAL RESEARCH (2014)
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
Akiyoshi Nakayama et al.
SCIENTIFIC REPORTS (2014)
Protein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients
Shunsuke Ito et al.
TOXINS (2014)
Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters
Zhibo Gai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients
Jente Boelaert et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)
Anita C. A. Dankers et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Albumin is the main plasma binding protein for indoxyl sulfate and p-cresyl sulfate
Liesbeth Viaene et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2013)
Precise Comparison of Protein Localization Among OCT, OAT, and MATE in Human Kidney
Hideyuki Motohashi et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway
Bertrand Gondouin et al.
KIDNEY INTERNATIONAL (2013)
The SLCO (former SLC21) superfamily of transporters
Bruno Hagenbuch et al.
MOLECULAR ASPECTS OF MEDICINE (2013)
Phosphate transporters of the SLC20 and SLC34 families
Ian C. Forster et al.
MOLECULAR ASPECTS OF MEDICINE (2013)
SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation
Anna Reznichenko et al.
PHYSIOLOGICAL GENOMICS (2013)
Indoxyl Sulfate Down-Regulates SLCO4C1 Transporter through Up-Regulation of GATA3
Yasutoshi Akiyama et al.
PLOS ONE (2013)
Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter
Carolien M. S. Schophuizen et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2013)
Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
Young-Hee Kim et al.
BMC PHARMACOLOGY & TOXICOLOGY (2013)
A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate
Yohei Miyamoto et al.
BIOCHEMICAL PHARMACOLOGY (2012)
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
Megan Roth et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Effects of phosphate on vascular function under normal conditions and influence of the uraemic state
Isabelle Six et al.
CARDIOVASCULAR RESEARCH (2012)
Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
Giuliano Ciarimboli et al.
CLINICAL CANCER RESEARCH (2012)
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
Hidemi Kajimoto et al.
KIDNEY INTERNATIONAL (2012)
Human serum albumin: From bench to bedside
Gabriella Fanali et al.
MOLECULAR ASPECTS OF MEDICINE (2012)
Indoxyl sulphate inhibits osteoclast differentiation and function
Anais Mozar et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)
Interaction between Two Sulfate-Conjugated Uremic Toxins, p-Cresyl Sulfate and Indoxyl Sulfate, during Binding with Human Serum Albumin
Hiroshi Watanabe et al.
DRUG METABOLISM AND DISPOSITION (2012)
Substrate recognition and translocation by polyspecific organic cation transporters
Hermann Koepsell
BIOLOGICAL CHEMISTRY (2011)
Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life
Pernille Bottger et al.
BMC BIOCHEMISTRY (2011)
Effects of Chronic Renal Failure on Kidney Drug Transporters and Cytochrome P450 in Rats
Judith Naud et al.
DRUG METABOLISM AND DISPOSITION (2011)
Analysis of Three-dimensional Systems for Developing and Mature Kidneys Clarifies the Role of OAT1 and OAT3 in Antiviral Handling
Megha A. Nagle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay
Raymond Calaf et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2011)
Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)
William R. Wikoff et al.
JOURNAL OF PROTEOME RESEARCH (2011)
OCT2 and MATE1 Provide Bidirectional Agmatine Transport
Tate N. Winter et al.
MOLECULAR PHARMACEUTICS (2011)
Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney
Yohei Miyamoto et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2011)
ABCG2 IS A HIGH-CAPACITY URATE TRANSPORTER AND ITS GENETIC IMPAIRMENT INCREASES SERUM URIC ACID LEVELS IN HUMANS
Akiyoshi Nakayama et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2011)
Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations
Henricus A. M. Mutsaers et al.
PLOS ONE (2011)
BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization
Junichi Shigeta et al.
CANCER SCIENCE (2010)
Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?
Suree Lekawanvijit et al.
EUROPEAN HEART JOURNAL (2010)
New loci associated with kidney function and chronic kidney disease
Anna Koettgen et al.
NATURE GENETICS (2010)
Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
Naoko Kimura et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Albumin thiol oxidation and serum protein carbonyl formation are progressively enhanced with advancing stages of chronic kidney disease
Yukie Matsuyama et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2009)
p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients
Bjoern. K. I. Meijers et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients
Fellype C. Barreto et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
K. K. Filipski et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
Interaction of Organic Cations with Organic Anion Transporters
Sun-Young Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation
Takafumi Toyohara et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
A review of albumin binding in CKD
Bjoern K. I. Meijers et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2008)
Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains
Pijun Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Membrane Topology of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Determined by Epitope Insertion and Immunofluorescence
Honggang Wang et al.
BIOCHEMISTRY (2008)
The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process
Masanori Tachikawa et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: Improvements by L-arginine intake
Hala O. El-Mesallamy et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2008)
Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
Adam L. VanWert et al.
MOLECULAR PHARMACOLOGY (2008)
OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
Zhi-Jun Wang et al.
PHARMACOGENETICS AND GENOMICS (2008)
Variability in human hepatic MRP4 expression: influence of cholestasis and genotype
U. Gradhand et al.
PHARMACOGENOMICS JOURNAL (2008)
Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats
Hong Lu et al.
DRUG METABOLISM AND DISPOSITION (2008)
Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements
Silvia Ravera et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters
Yuko Tanihara et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties
K. Oettl et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats
Kumiko Nishihara et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine
Sofia Berggren et al.
MOLECULAR PHARMACEUTICS (2007)
Down-regulation of intestinal drug transporters in chronic renal failure in rats
Judith Naud et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2-and MRP4/ABCC4-mediated methotrexate transport
Azza A. K. El-Sheikh et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Investigation of an albumin-enriched fraction of human serum and its albuminome
Rebekah L. Gundry et al.
PROTEOMICS CLINICAL APPLICATIONS (2007)
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
K. Bleasby et al.
XENOBIOTICA (2006)
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
Satohiro Masuda et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Identification and characterization of oxidized human serum albumin - A slight structural change impairs its ligand-binding and antioxidant functions
Asami Kawakami et al.
FEBS JOURNAL (2006)
Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification
XW Li et al.
CIRCULATION RESEARCH (2006)
Allosteric modulation of drug binding to human serum albumin
P Ascenzi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
H Kubota et al.
EPILEPSY RESEARCH (2006)
Structural basis of the drug-binding specificity of human serum albumin
J Ghuman et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats
T Deguchi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure
N Eto et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats
T Deguchi et al.
PHARMACEUTICAL RESEARCH (2005)
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
T Mikkaichi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney
Y Urakami et al.
PHARMACEUTICAL RESEARCH (2004)
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
G Reid et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Review on uremic toxins:: Classification, concentration, and interindividual variability
R Vanholder et al.
KIDNEY INTERNATIONAL (2003)
Uremic toxins overload accelerates renal damage in a rat model of chronic renal failure
M Satoh et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2003)
Evolution of oxidative stress and inflammation during hemodialysis and their contribution to cardiovascular disease
ML Wratten et al.
ANTIOXIDANTS & REDOX SIGNALING (2002)
Localisation of breast cancer resistance protein in microvessel endothelium of human brain
HC Cooray et al.
NEUROREPORT (2002)
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
L Ji et al.
KIDNEY INTERNATIONAL (2002)
Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity
A Enomoto et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney
T Deguchi et al.
KIDNEY INTERNATIONAL (2002)
Albumin is the major plasma protein target of oxidant stress in uremia
J Himmelfarb et al.
KIDNEY INTERNATIONAL (2001)
Effect of oxidative stress on the structure and function of human serum albumin
M Anraku et al.
PHARMACEUTICAL RESEARCH (2001)
Oxidation of albumin is enhanced in the presence of uremic toxins
ML Wratten et al.
RENAL FAILURE (2001)
Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
Y Zhang et al.
BRAIN RESEARCH (2000)