期刊
TOXINS
卷 14, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/toxins14060386
关键词
mycotoxin; zearalenone; risk assessment; toxicity; intestinal health; endocrine interference
资金
- National Natural Science Foundation of China (NSFC) [32001807]
- Key Research and Development Project of Hebei Province [21372801D]
This paper introduces the production, properties, and toxicology research progress of zearalenone, focusing on its effects on genetics, reproduction, liver, immunity, carcinogenicity, endocrine interference, and intestinal health. The progress of human exposure risk assessment is also summarized.
Zearalenone, a mycotoxin produced by fungi of the genus Fusarium, widely exists in animal feed and human food. The structure of zearalenone is similar to estrogen, so it mainly has estrogenic effects on various organisms. Products contaminated with zearalenone can pose risks to animals and humans. Therefore, it is imperative to carry out toxicological research on zearalenone and evaluate its risk to human health. This paper briefly introduces the production, physical, and chemical properties of zearalenone and the research progress of its toxicity kinetics, focusing on its genetic toxicity, reproductive toxicity, hepatotoxicity, immunotoxicity, carcinogenicity, endocrine interference, and its impact on intestinal health. Finally, the progress of the risk assessment of human exposure is summarized to provide a reference for the follow-up study of zearalenone.
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