期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 11, 期 4, 页码 383-393出版社
OXFORD UNIV PRESS
DOI: 10.1093/stcltm/szac006
关键词
neural stem; progenitor cells; Parkinson's disease; cell transplantation; meta-analysis; rodent animals
资金
- National Natural Science Foundation of China (NSFC) [81571242, 81901895]
- China Scholarship Council (CSC)
A meta-analysis of studies on rodent animal models of Parkinson's disease (PD) found that unmodified neural stem/progenitor cells (NSPCs) therapy can attenuate behavioral deficits and increase dopaminergic neurons, supporting the consideration of early-stage clinical trials of NSPCs in PD patients.
The effects of neural stem/progenitor cells (NSPCs) have been extensively evaluated by multiple studies in animal models of Parkinson's disease (PD), but the therapeutic efficacy was inconsistent. Here, we searched 4 databases (PubMed, Embase, Scopus, and Web of Science) and performed a meta-analysis to estimate the therapeutic effects of unmodified NSPCs on neurological deficits in rodent animal models of PD. Data on study quality score, behavioral outcomes (apomorphine or amphetamine-induced rotation and limb function), histological outcome (densitometry of TH+ staining in the SNpc), and cell therapy-related severe adverse events were extracted for meta-analysis and systematic review. Twenty-one studies with a median quality score of 6 (range from 4 to 9) in 11 were examined. Significant improvement was observed in the overall pooled standardized mean difference (SMD) between animals transplanted with NSPCs and with control medium (1.22 for apomorphine-induced rotation, P < .001; 1.50 for amphetamine-induced rotation, P < .001; 0.86 for limb function, P < .001; and -1.96 for the densitometry of TH+ staining, P < .001). Further subgroup analysis, animal gender, NSPCs source, NSPCs dosage, and pretreatment behavioral assessment were closely correlated with apomorphine-induced rotation and amphetamine-induced rotation. In conclusion, unmodified NSPCs therapy attenuated behavioral deficits and increased dopaminergic neurons in rodent PD models, supporting the consideration of early-stage clinical trial of NSPCs in patients with PD.
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