期刊
POLYMERS
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/polym14091918
关键词
phase-separation; chromatin organization; polymer physics; gene regulation; molecular dynamics; phase transitions
资金
- Programma per il Finanziamento della Ricerca di Ateneo Linea B (FRA) 2020, University of Naples Federico II
- CINECA ISCRA grant [HP10CCZ4KN]
Biophysical processes within cell nuclei play a crucial role in genome activities. Polymer physics models in synergy with numerical simulations are beneficial for studying various aspects of genome functions.
Within cell nuclei, several biophysical processes occur in order to allow the correct activities of the genome such as transcription and gene regulation. To quantitatively investigate such processes, polymer physics models have been developed to unveil the molecular mechanisms underlying genome functions. Among these, phase-separation plays a key role since it controls gene activity and shapes chromatin spatial structure. In this paper, we review some recent experimental and theoretical progress in the field and show that polymer physics in synergy with numerical simulations can be helpful for several purposes, including the study of molecular condensates, gene-enhancer dynamics, and the three-dimensional reconstruction of real genomic regions.
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