4.7 Article

Evaluation of the Performance of a ZnO-Nanoparticle-Coated Hydrocolloid Patch in Wound Healing

期刊

POLYMERS
卷 14, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/polym14050919

关键词

wound healing; hydrocolloid; ZnO-NPs; inflammation; proliferation

资金

  1. SNUBH Research Fund [14-2019-0003]
  2. Institute of Information, the Technology development Program - Ministry of SMEs and Startups (MSS, Korea) [S2942288]
  3. Communications Technology Planning and Evaluation (IITP) grant - Korean government (MSIT) [2020-0-00990]
  4. Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2942288] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Hydrocolloid dressings combined with zinc oxide nanoparticles were found to accelerate wound healing rates, reduce inflammation, and promote the proliferation phase of the healing process. This cost-effective and UV-blocking treatment showed significant improvements in both in vivo and in vitro models, providing a promising approach for wound dressing.
Hydrocolloid dressings are an important method for accelerating wound healing. A combination of a hydrocolloid and nanoparticles (NPs), such as gold (Au), improves the wound healing rate, but Au-NPs are expensive and unable to block ultraviolet (UV) light. Herein, we combined zinc oxide nanoparticles (ZnO-NPs) with hydrocolloids for a less expensive and more effective UV-blocking treatment of wounds. Using Sprague-Dawley rat models, we showed that, during 10-day treatment, a hydrocolloid patch covered with ZnO-NPs (ZnO-NPs-HC) macroscopically and microscopically stimulated the wound healing rate and improved wound healing in the inflammation phase as shown by reducing of pro-inflammatory cytokines (CD68, IL-8, TNF-alpha, MCP-1, IL-6, IL-1 beta, and M1) up to 50%. The results from the in vitro models (RAW264.7 cells) also supported these in vivo results: ZnO-NPs-HCs improved wound healing in the inflammation phase by expressing a similar level of pro-inflammatory mediators (TNF-alpha and IL-6) as the negative control group. ZnO-NPs-HCs also encouraged the proliferation phase of the healing process, which was displayed by increasing expression of fibroblast biomarkers (alpha-SMA, TGF-beta 3, vimentin, collagen, and M2) up to 60%. This study provides a comprehensive analysis of wound healing by measuring the biomarkers in each phase and suggests a cheaper method for wound dressing.

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