期刊
POLYMERS
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/polym14091674
关键词
poly(ester urethane)s; cost-effective; bio-degradable; ordered hard segments
资金
- Undergraduate Training Programs for Innovation and Entrepreneurship, Shandong Normal University, China [2021150103]
- Scientific Research Fund Project of Undergraduates, Shandong Normal University, China [BKJJ2021047]
The article describes a simple methodology to prepare cost-effective biodegradable poly(ester urethane)s (PEUs) with ordered hard segments (OHS) for long-term medical implants. The introduction of OHS contributes to improved physical and chemical features of PEU films, including tensile strength, water absorption, and degradation rate. PEUs also exhibit good cytocompatibility.
The article below describes a simple methodology to prepare cost-effective biodegradable poly(ester urethane)s (PEUs) with ordered hard segments (OHS) for medical application as long-term implants. A low-cost diurethane diol (1,4-butanediol-hexanediisocyanate-1,4-butanediol, BHB) was first designed and synthesized. Consequently, the BHB was employed as a chain extender to react with NCO-terminated poly(epsilon-caprolactone) to obtain PEUs. The molecular structural formats for BHB and PEUs were defined through NMR, FT-IR, and MS together with GPC, while the influence of OHS content on physical/chemical features for casted PEU films was investigated. The introduction of OHS could contribute to forming denser hydrogen-bonds, and consequently produce a compact network structure, resulting in great tensile capacity, low water absorption, and slow hydrolytic degradation rate by PEU films. PEU-2.0 films, which possessed the highest OHS content within PEUs, exhibited 40.6 MPa tensile strength together with 477% elongation at break, 4.3 wt % equilibrium water absorption and only 29.5% weight loss post-12 months' degradation. In addition, cytotoxicity analysis of film extracts indicated that the cell viability of all PEUs containing OHS exceeded 75%, indicating good cytocompatibility. Due to outstanding tensile features, high biostability, nontoxic and absorbable degradation products and acceptable cytocompatibility, the cost-effective materials exhibited promising applications in the field of long-term implants.
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