期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 27, 页码 13918-13925出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C116.736702
关键词
Arabidopsis thaliana; G protein; phosphorylation; receptor protein serine; threonine kinase; regulator of G protein signaling (RGS); receptor-like kinases; BAK1; FLS2; flg22; AtRGS1
资金
- National Institutes of Health-NCI [CA016086]
Plants and some protists have heterotrimeric G protein complexes that activate spontaneously without canonical G protein-coupled receptors (GPCRs). In Arabidopsis, the sole 7-transmembrane regulator of G protein signaling 1 (AtRGS1) modulates the G protein complex by keeping it in the resting state (GDP-bound). However, it remains unknown how a myriad of biological responses is achieved with a single G protein modulator. We propose that in complete contrast to G protein activation in animals, plant leucine-rich repeat receptor-like kinases (LRR RLKs), not GPCRs, provide this discrimination through phosphorylation of AtRGS1 in a ligand-dependent manner. G protein signaling is directly activated by the pathogen-associated molecular pattern flagellin peptide 22 through its LRR RLK, FLS2, and co-receptor BAK1.
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