期刊
POLYMERS
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/polym14101955
关键词
core-sheath nanofibers; chitosan; cyclodextrin polymer; polyelectrolyte complex; triclosan release; antimicrobial properties
资金
- Conseil Regional des Hauts-de-France
- European Regional Development Fund (ERDF)
This study focuses on the preparation of core-sheath nanofibers using chitosan and cyclodextrin polymer, and investigates the stability, release behavior, and antibacterial activity of triclosan-loaded nanofibers in aqueous medium. The results indicate that the type of nanofibers directly affects the release and antibacterial activity of triclosan.
This work focuses on the manufacture of core-sheath nanofibers (NFs) based on chitosan (CHT) as sheath and cyclodextrin polymer (PCD) as core and loaded with triclosan (TCL). In parallel, monolithic NFs consisting of blended CHT-PCD and TCL were prepared. Nanofibers were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier Transform Infrared spectroscopy (FTIR). SEM displayed the morphology of NFs and the structure of the nanowebs, while TEM evidenced the core-sheath structure of NFs prepared by coaxial electrospinning. The core diameters and sheath thicknesses were found dependent on respective flow rates of both precursor solutions. Nanofibers stability and TCL release in aqueous medium were studied and correlated with the antibacterial activity against Staphylococcus aureus and Escherichia coli. Results showed that the release profiles of TCL and therefore the antibacterial activity were directly related to the type of nanofibers. In the case of monolithic nanofibers, the NFs matrix was composed of polyelectrolyte complex (PEC formed between CHT and PCD) and resulted in a prolonged release of TCL and a sustained antibacterial effect. In the case of core-sheath NFs, the PEC was formed only at the core-sheath interface, leading to less stable NFs and therefore to a faster release of TCL, and to a less extended antibacterial activity compared to monolithic ones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据