期刊
PLOS PATHOGENS
卷 18, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1010424
关键词
-
资金
- National Institute of General Medical Sciences [R35 GM137934]
Fatty acid-and retinol-binding proteins (FARs) are a class of secreted proteins found exclusively in nematodes. Recent research has shown their involvement in immunomodulation.
Fatty acid-and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.
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