期刊
PLOS NEGLECTED TROPICAL DISEASES
卷 16, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0010251
关键词
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资金
- company Merck Sharp and Dohme (MSD) Animal Health Innovation GmbH
- Bahia State Research Support Foundation (FAPESB)
- State University of Santa Cruz (UESC)
- Coordination for the Improvement of Higher Education Personnel Brazil (CAPES) [001]
This study evaluated the therapeutic and residual efficacy of fluralaner for treating tungiasis in dogs. The results showed that a single oral administration of fluralaner is effective in treating and achieving long-lasting prevention for tungiasis in dogs.
The sand flea Tunga penetrans is one of the zoonotic agents of tungiasis, a parasitic skin disease of humans and animals. The dog is one of its main reservoirs. This negatively controlled, randomized, double-masked clinical trial evaluated the therapeutic and residual efficacy of fluralaner for treatment of dogs naturally infested with T. penetrans. Sixty-two dogs from an endemically affected community in Brazil were randomly assigned to either receive oral fluralaner (Bravecto chewable tablets) at a dose of 25 to 56 mg fluralaner/kg body weight, or no treatment (31 dogs per group). Dogs were clinically examined using a severity score for acute canine tungiasis (SCADT), parasitological examinations as defined by the Fortaleza classification, and pictures of lesions on days 0 (inclusion and treatment), 7 +/- 2, 14 +/- 2, 21 +/- 2, 28 +/- 2, 60 +/- 7, 90 +/- 7, 120 +/- 7 and 150 +/- 7. The percentage of parasite-free dogs after treatment was >90% between days 14 and 90 post-treatment with 100% efficacy on study days 21, 28 and 60. Sand flea counts on fluralaner treated dogs were significantly lower (p<0.025) than control dogs on all counts from day 7 to 120. The number of live sand fleas on treated dogs was reduced by > 90% on day 7, > 95% on days 14 and 90, and 100% from day 21 to 60, and with a significant difference between groups from day 7 to 120. From day 7 to day 120, mean SCADT scores were significantly reduced in treated dogs with a mean of 0.10 compared to 1.54 on day 120 in untreated dogs. Therefore, a single oral fluralaner administration is effective for treating and achieving long lasting (> 12 weeks) prevention for tungiasis in dogs.
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