Risk stratification of adolescents for the screening of non-alcoholic fatty liver disease

Article Gastroenterology & Hepatology

Intensive Lifestyle Management Improves Steatosis and Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease

Sander Lefere et al.

Summary: NAFLD and associated fibrosis are highly prevalent in children and adolescents with severe obesity. An intensive multidisciplinary lifestyle management program not only improves liver steatosis, but also fibrosis.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Prevalence of Liver Steatosis and Fibrosis Detected by Transient Elastography in Adolescents in the 2017-2018 National Health and Nutrition Examination Survey

Stefano Ciardullo et al.

Summary: The prevalence of MAFLD and significant fibrosis is alarmingly high among adolescents in the National Health and Nutrition Examination Survey 2017-2018. Factors such as body mass index, sex, ethnicity, and hypertension are associated with steatosis, while factors like body mass index and ethnicity are associated with significant fibrosis. Effective noninvasive strategies are urgently needed to differentiate simple steatosis from progressive forms.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Pediatrics

Serum Alanine Transaminase Is an Inadequate Nonalcoholic Fatty Liver Screening Test in Adolescents: Results From the National Health and Nutrition Examination Survey 2017-2018

Gary A. Abrams et al.

Summary: In a nationally representative sample of overweight and obese adolescents, serum ALT level did not function adequately as a screening test to detect NAFLD. Despite higher average ALT levels in subjects with NAFLD, ALT provided minimal discrimination capability with AUROC values of .66 in males and .67 in females.

CLINICAL PEDIATRICS (2021)

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Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality

Tracey G. Simon et al.

Summary: The study revealed that Swedish children and young adults with biopsy-confirmed NAFLD have significantly higher rates of overall, cancer-, liver- and cardiometabolic-specific mortality compared to matched general population controls.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology