期刊
MOLECULAR BRAIN
卷 15, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13041-022-00934-7
关键词
Depression; Suicide; Habenula; Postmortem; Gene expression; Transcriptome
资金
- National Research Foundation of Korea (NRF) - Korea Government Ministry of Science and ICT [NRF2019M3C7A1032764, NRF-2017M3C7A1079692]
- Korea University Research Grants
Through postmortem gene expression analysis, 251 differentially expressed genes (DEGs) were identified in the Hb tissue of suicides compared to Hb tissues from neurotypical individuals. Subsequent bioinformatic analyses using single-cell transcriptome data from the mouse Hb revealed that a subset of endothelial cell-enriched genes and their putative upstream transcriptional regulators were significantly affected in suicides. Despite being based on a limited number of samples, the study suggests a potential association of endothelial dysfunction in the Hb with depression and suicidal behavior.
The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic systems. As an anti-reward center, it has been implicated in the etiology of various neuropsychiatric disorders, particularly those associated with dysregulated reward circuitry. In this regard, Hb has been proposed as a therapeutic target for treatment-resistant depression associated with a higher risk of suicide. Therefore, we aimed to gain insight into the molecular signatures of the Hb in association with suicide in individuals with major depression. Postmortem gene expression analysis identified 251 differentially expressed genes (DEGs) in the Hb tissue of suicides in comparison with Hb tissues from neurotypical individuals. Subsequent bioinformatic analyses using single-cell transcriptome data from the mouse Hb showed that the levels of a subset of endothelial cell-enriched genes encoding cell-cell junctional complex and plasma membrane-associated proteins, as well as the levels of their putative upstream transcriptional regulators, were significantly affected in suicides. Although our findings are based on a limited number of samples, the present study suggests a potential association of endothelial dysfunction in the Hb with depression and suicidal behavior.
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