期刊
JOURNAL OF PARKINSONS DISEASE
卷 12, 期 -, 页码 S65-S74出版社
IOS PRESS
DOI: 10.3233/JPD-223152
关键词
Parkinson's disease; T cells; CD4+T cells; CD8+T cells; neuroinflammation; peripheral immunity
资金
- Fondazione CARIPLO [2011-0504]
- AGING PROJECTDepartment of Excellence-Universit`a del Piemonte Orientale
This review discusses the involvement of T cells in Parkinson's disease, highlighting their roles in both the central and peripheral nervous system, their significance as biomarkers of disease progression, and recent therapeutic strategies targeting T cell response.
T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.
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