Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p

Article Biochemistry & Molecular Biology

Circular RNA circ_0001017 Sensitizes Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy by the miR-543/PHLPP2 Axis

Jianmin Zhang et al.

Summary: The study demonstrated that enforced expression of circ_0001017 suppressed malignant behaviors and enhanced CDDP sensitivity of CDDP-resistant GC cells at least partially by the miR-543/PHLPP2 axis.

BIOCHEMICAL GENETICS (2022)

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Article Gastroenterology & Hepatology

CircRNA Hsa_circ_0001017 Inhibited Gastric Cancer Progression via Acting as a Sponge of miR-197

Hui Li et al.

Summary: The study revealed that the upregulation of hsa_circ_0001017 significantly inhibited proliferation and metastasis of gastric cancer cell lines by targeting the miR-197/RHOB signaling pathway. The findings suggest that hsa_circ_0001017 could serve as a potential biomarker for gastric cancer treatment.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Medicine, General & Internal

Small interfering RNAs in tendon homeostasis

Giuseppe Gargano et al.

Summary: SiRNA can participate in the process of tendon healing and identify potential therapeutic targets. However, there is controversy over the regulation of genes and growth factors involved in tendon diseases and healing processes by siRNAs.

BRITISH MEDICAL BULLETIN (2021)

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Article Cell Biology

Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR-1227/IRF2 axis

Xin Jiang et al.

Summary: The study demonstrated that circ-0000658 can modulate the proliferation and invasion of osteosarcoma cells through the miR-1227/IRF2 axis, suggesting that circ-0000658 may serve as a potential therapeutic target for osteosarcoma.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Medicine, Research & Experimental

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

Zizheng Chen et al.

Summary: This study identified up-regulated circCAMSAP1 in osteosarcoma, which promotes tumorigenesis through the circCAMSAP1/miR-145-5p/FLI1 pathway, suggesting it as a potential therapeutic target for human osteosarcoma.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Engineering, Biomedical

Osteosarcoma: a review of current and future therapeutic approaches

Xin Zhao et al.

Summary: Osteosarcoma is a common primary bone malignancy that poses a serious threat to human health globally, characterized by high malignancy and rapid progression. The incidence of osteosarcoma has a bimodal distribution pattern with peaks in different age groups, mainly presenting as single lesions. This article summarizes the types, clinical diagnosis, and treatment methods of osteosarcoma.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Article Oncology

Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression

Feng Liu et al.

Summary: The circRNA circ_0088212 may act as a tumor suppressor in osteosarcoma by sequestering miR-520 h from APOA1, suggesting the circ_0088212/miR-520 h/APOA1 axis as a promising therapeutic target for intervention in osteosarcoma.

TRANSLATIONAL ONCOLOGY (2021)

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Article Medicine, Research & Experimental

Suppression of circ_0008932 inhibits tumor growth and metastasis in osteosarcoma by targeting miR-145-5p

Chenggang Cao et al.

Summary: Osteosarcoma is a common malignant tumor and the study found that circ_0008932 is upregulated in most primary OS tumors, indicating its association with OS development. Silencing circ_0008932 inhibited the proliferation, migration, and invasion of OS cells while promoting apoptosis. Circ_0008932 may act as an oncogenic factor targeting miR-145-5p and could be a potential therapeutic target for OS.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Medicine, General & Internal

Circular RNA circ_0046264 Suppresses Osteosarcoma Progression via microRNA-940/Secreted Frizzled Related Protein 1 Axis

Rui Du et al.

Summary: This study revealed that circ_0046264 is down-regulated in osteosarcoma and functions as a tumor suppressor by modulating the miR-940/SFRP1 axis to inhibit proliferation, migration, and invasion of tumor cells.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Neurosciences

Hsa_circ_0001017 inhibits proliferation and metastasis via regulating the let-7g-3p/NDST3 axis in glioma

Tao Li et al.

Summary: The study reveals that Hsa_circ_0001017 is downregulated in glioma tissues and cells, and its overexpression inhibits proliferation, migration, and invasion of glioma cells while promoting apoptosis.

FOLIA NEUROPATHOLOGICA (2021)

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Article Oncology