Phillygenin Protects the Intestinal Barrier from Dysfunction via let-7b Signaling Pathway and Regulation of Intestinal Microbiota

Article Gastroenterology & Hepatology

Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling

Xiaomei Li et al.

Summary: The study revealed that sodium nitroprusside alleviates HFD-induced gut dysfunction by activating the AMPK/SIRT1 signaling pathway, leading to improvements in intestinal barrier function and gut microbiota dysbiosis.

BMC GASTROENTEROLOGY (2021)

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Article Pharmacology & Pharmacy

Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway

Mengting Zhou et al.

Summary: Our research demonstrated that PHI significantly inhibited the increase of IL-1β and PGE2 and reduced the expression of inflammatory genes including IL-6, IL-1β, and PGE2 in LPS-stimulated RAW264.7 cells. Proteomics analysis revealed that PHI regulated multiple signaling pathways, while molecular docking studies suggested an affinity of PHI for proteins in the NF-κB pathway. Western blot analysis confirmed that PHI suppressed LPS-induced NF-κB pathway activation, showing a strong anti-inflammatory effect.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota

Cheng Wang et al.

Summary: The study demonstrated that PHI can protect the intestinal epithelial barrier and attenuate CCl4-induced liver fibrosis by modulating inflammation and gut microbiota. PHI showed potential as a therapeutic agent for liver fibrosis by promoting the expression of intestinal barrier markers and enriching the abundance of beneficial bacteria such as Lactobacillus.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

A natural product phillygenin suppresses osteosarcoma growth and metastasis by regulating the SHP-1/JAK2/STAT3 signaling

Xiaomin Ding et al.

Summary: Phillygenin was found to inhibit the growth and motility of osteosarcoma cells by blocking the STAT3 signaling pathway, particularly by regulating Janus kinase 2 and Src homology region 2 domain-containing phosphatase 1. It also showed potential in repressing osteosarcoma progression by inhibiting gene products regulated by STAT3.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Article Biotechnology & Applied Microbiology