4.2 Article

Phillygenin Protects the Intestinal Barrier from Dysfunction via let-7b Signaling Pathway and Regulation of Intestinal Microbiota

期刊

JOURNAL OF HEALTHCARE ENGINEERING
卷 2022, 期 -, 页码 -

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HINDAWI LTD
DOI: 10.1155/2022/4769709

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资金

  1. Guangzhou Science and Technology Plan Joint Foundation of City and University [202102010085]
  2. University-Industry Cooperation Innovation Foundation of Science and Technology Development Center of the Ministry of Education [2021JH016]
  3. Major Scientific Research Projects at Provincial Level in Guangdong General University [2017KZDXM068]
  4. Innovation Team Project of Guangzhou Education Bureau [201831828]

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This study investigates the positive effects of phillygenin on intestinal tight junctions through the let-7b signaling pathway and regulation of intestinal microbiota. Results show that phillygenin can protect the intestinal barrier and maintain the expression of tight junction-associated proteins. Clinical samples confirm the regulatory role of phillygenin on let-7b levels.
The study investigates the positive effects of phillygenin on intestinal tight junction via the let-7b signaling pathway and the regulation of intestinal microbiota. The expression levels of tight junction proteins are determined through PCR and Western blot. DSS-induced mice colitis is used to verify the protective effects of phillygenin on intestinal barrier and tight junction. Fecal microbiota transplantation is used to verify the role intestinal microbiota. let-7b is detected in the colon tissues of patients with acute stercoral obstruction. Phillygenin could promote the expression of occludin, which might be inhibited by let-7b inhibitor. DSS-induced mice colitis showed that phillygenin could lower the colonic permeability and maintain the tight junction-associated proteins. The effects of phillygenin could be deprived by anti-let-7b and rescued by FMT of normal intestinal microbiota. Clinical samples verified a lower level of let-7b in stercoral obstruction patients. Phillygenin could protect the intestinal barrier from dysfunction via the signaling pathway of let-7b by regulating intestinal microbiota.

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