期刊
CANCER LETTERS
卷 361, 期 1, 页码 174-184出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.03.005
关键词
NFAT; Calcineurin; Tumor microenvironment; Metastasis; Drug resistance
类别
资金
- National Natural Science Foundation of China [81272593, 81372621]
Since nuclear factor of activated T cells (NFAT) was first identified as a transcription factor in T cells, various NFAT isoforms have been discovered and investigated. Accumulating studies have suggested that NFATs are involved in many aspects of cancer, including carcinogenesis, cancer cell proliferation, metastasis, drug resistance and tumor microenvironment. Different NFAT isoforms have distinct functions in different cancers. The exact function of NFAT in cancer or the tumor microenvironment is context dependent. In this review, we summarize our current knowledge of NFAT regulation and function in cancer development and treatment. NFATs have emerged as a potential target for cancer prevention and therapy. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
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