4.4 Review

International consensus statement on allergy and rhinology: Olfaction

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Summary: This study evaluated the correlation and agreement between the Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test - University of Pennsylvania Smell Identification Test in both healthy participants and participants with olfactory disorders. The results showed that both tests were effective in distinguishing groups, and there was a strong correlation and agreement between the tests.

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Summary: This study investigated olfactory function and smoking habits in patients with olfactory loss caused by different etiologies, finding an association between current smoking and posttraumatic olfactory loss, but no association between a history of smoking and lower olfactory scores.

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A New Method for Assessment of Retronasal Olfactory Function

Ayaho Yoshino et al.

Summary: The study developed a test for assessing retronasal olfaction in healthy individuals and patients with olfactory disorders using tasteless powders. Results showed high correlation between retronasal and orthonasal olfaction, with 16 stimuli effectively differentiating patients from controls.

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Summary: Olfactory dysfunction (OD) is common and has been reported as an early indicator of COVID-19. The prevalence of OD in the general population depends on the testing method and population age, with greater prevalence in studies using objective tests and older subjects.

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Bo Yoon Choi et al.

Summary: This study demonstrated the efficacy of olfactory training (OT) in postinfectious olfactory dysfunction (PIOD) patients using odorants familiar to Koreans and including a control group. OT improved olfactory function in approximately 40% of patients over 12 weeks, with the OT group showing significantly better results in olfactory tests compared to the non-OT group.

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18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?

E. Guedj et al.

Summary: Several brain complications have been reported in COVID-19 patients, suggesting potential neurotropism and delayed outbreak of neuroinflammatory diseases. PET metabolism analysis showed hypometabolism in the olfactory/rectus gyrus and other brain regions, supporting the neurotropism hypothesis. Further post-viral cohort studies are needed to determine the exact relationship between these hypometabolisms and persistent disorders.

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Evaluating the Relationship Between Olfactory Function and Loneliness in Community-Dwelling Individuals: A Cross-sectional Study

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Normal Olfactory Functional Connectivity Despite Lifelong Absence of Olfactory Experiences

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Subtle olfactory dysfunction after SARS-CoV-2 virus infection in children

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