4.6 Article

Oral Mucosa Derived a-Synuclein as a Potential Diagnostic Biomarker for Parkinson's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

An Update on the Critical Role of α-Synuclein in Parkinson's Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels

Iris N. Serratos et al.

Summary: The aggregation of alpha-synuclein plays a critical role in the development of Parkinson's disease and other synucleinopathies. Changes in protein conformation due to mutations and post-translational modifications lead to the abnormal aggregation of alpha-synuclein, which contributes to the progression of these diseases.

MOLECULAR NEUROBIOLOGY (2022)

Article Clinical Neurology

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Zerui Wang et al.

Summary: The study demonstrates that skin alpha Syn(P) seeding activity can potentially serve as a novel biomarker for antemortem diagnosis of Parkinson disease (PD) and other synucleinopathies. The analysis of skin samples from autopsies and biopsies shows a significant increase in alpha Syn(P) seeding activity in individuals with PD and synucleinopathies compared to controls with tauopathies and non-neurodegenerative diseases.

JAMA NEUROLOGY (2021)

Article Cell Biology

Distribution of α-synuclein in normal human jejunum and its relations with the chemosensory and neuroendocrine system

Arianna Casini et al.

Summary: This study detected the presence of alpha-syn in the normal human jejunal wall, localized not only in the ENS but also in epithelial cells, particularly in EECs. These findings suggest that alpha-syn may play a role in synaptic transmission of the ENS and contribute to maintaining the integrity of the small intestine epithelial barrier through EECs.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

Review Neurosciences

Neuropathology and molecular diagnosis of Synucleinopathies

Shunsuke Koga et al.

Summary: Synucleinopathies are a group of diseases characterized by pathological aggregates of alpha-synuclein in neurons and glia. The two main disease entities are Lewy body disease and multiple system atrophy, each with different clinical subtypes. Currently, there are no disease-modifying therapies, but research on molecular mechanisms provides hope for future treatments.

MOLECULAR NEURODEGENERATION (2021)

Article Clinical Neurology

Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort

Nour K. Majbour et al.

Summary: This study investigated CSF biomarkers levels in newly diagnosed Parkinson's disease patients, finding that CSF oligomeric alpha-synuclein increased with disease severity and reflected PD motor trajectories.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Prevalence of Parkinson's Disease: A Community-Based Study in China

Shige Qi et al.

Summary: A nationwide study in 2015 found that the prevalence of Parkinson's disease in Chinese individuals aged 60 years or older was 1.37%, with an estimated total of 3.62 million people in China living with PD. Although the percentage of PD prevalence did not change significantly, the increasing population has led to a rise in the total number of PD patients, posing a significant challenge in a rapidly aging population.

MOVEMENT DISORDERS (2021)

Article Microbiology

Oral Factors That Impact the Oral Microbiota in Parkinson's Disease

Natalia S. Rozas et al.

Summary: This study found significant differences in the oral microbiota of patients with PD compared to healthy controls, possibly due to factors such as dysphagia, drooling, and salivary pH. Understanding the factors influencing their oral microbiota could lead to the development of diagnostic and treatment strategies to improve the quality of life and survival of these patients.

MICROORGANISMS (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Parkinson Disease A Review

Melissa J. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Neurosciences

Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing

Lorenzo Brozzetti et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Medicine, General & Internal

Diagnostic Biomarkers for Alzheimer's Disease Using Non-Invasive Specimens

Maria Paraskevaidi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Clinical Neurology

Alpha-synuclein in erythrocyte membrane of patients with multiple system atrophy: A pilot study

Genliang Liu et al.

PARKINSONISM & RELATED DISORDERS (2019)

Article Medicine, Research & Experimental

Expression of A42, -Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer's Disease and Rate of Aging

V. A. Zuev et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Neurosciences

Erythrocytic α-Synuclein as a potential biomarker for Parkinson's disease

Chen Tian et al.

TRANSLATIONAL NEURODEGENERATION (2019)

Article Neurosciences

Nitrated alpha-synuclein in minor salivary gland biopsies in Parkinson's disease

Ling-Yan Ma et al.

NEUROSCIENCE LETTERS (2019)

Review Biochemistry & Molecular Biology

Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease

Ling-Yan Ma et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Article Medicine, Research & Experimental

Cell Biology and Pathophysiology of α-Synuclein

Jacqueline Burre et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Article Multidisciplinary Sciences

Quantitation of the cellular content of saliva and buccal swab samples

Christiane Theda et al.

SCIENTIFIC REPORTS (2018)

Article Clinical Neurology

Tau Protein in Oral Mucosa and cognitive state: a cross-sectional study

Luis Fernando Arredondo et al.

FRONTIERS IN NEUROLOGY (2017)

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Clinical Neurology

High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease

Maxime Francois et al.

CURRENT ALZHEIMER RESEARCH (2016)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Article Neurosciences

Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk

Wayne R. Leifert et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Clinical Neurology

Biomarkers of Alzheimer's Disease Risk in Peripheral Tissues; Focus on Buccal Cells

Maxime Francois et al.

CURRENT ALZHEIMER RESEARCH (2014)

Article Clinical Neurology

Multiple Organ Involvement by Alpha-Synuclein Pathology in Lewy Body Disorders

Ellen Gelpi et al.

MOVEMENT DISORDERS (2014)

Article Biochemical Research Methods

Buccal micronucleus cytome assay

Philip Thomas et al.

NATURE PROTOCOLS (2009)