期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.897688
关键词
retromer; membrane trafficking; neurodegeneration; Alzheimer's Disease; Parkinson's disease
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [19K16998]
- Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development (AMED)
- Biogen Research Grants
- Grants-in-Aid for Scientific Research [19K16998] Funding Source: KAKEN
Retromer is a protein complex involved in retrograde cargo sorting, which is closely related to neurodegenerative diseases. Dysfunction of retromer has been found to be involved in the pathogenesis of Alzheimer's Disease and Parkinson's disease. Targeting retromer may present a potential therapeutic strategy for these neurodegenerative diseases.
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them to the trans-Golgi network or to the plasma membrane. In addition to the endosomal trafficking, the retromer machinery participates in mitochondrial dynamics and autophagic processes and thus contributes to cellular homeostasis. The retromer components and their associated molecules are expressed in different types of cells including neurons and glial cells, and accumulating evidence from genetic and biochemical studies suggests that retromer dysfunction is profoundly involved in the pathogenesis of neurodegenerative diseases including Alzheimer's Disease and Parkinson's disease. Moreover, targeting retromer components could alleviate the neurodegenerative process, suggesting that the retromer complex may serve as a promising therapeutic target. In this review, we will provide the latest insight into the regulatory mechanisms of retromer and discuss how its dysfunction influences the pathological process leading to neurodegeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据