4.6 Article

Functional Connectivity Hypointensity of Middle Cingulate Gyrus and Thalamus in Age-Related Macular Degeneration Patients: A Resting-State Functional Magnetic Resonance Imaging Study

期刊

FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.854758

关键词

age-related macular degeneration; rs-fMRI; functional connectivity; middle cingulate gyrus; thalamus

资金

  1. Jiangxi branch of National Clinical Research Center for ocular disease [20211ZDG02003]
  2. Key Research Foundation of Jiangxi Province [20203BBG73058, 20192BBGL70033]
  3. Excellent Talents Development Project of Jiangxi Province [20192BCBL23020]
  4. Natural Science Foundation of Jiangxi Province [20181BAB205034]
  5. Grassroots Health Appropriate Technology Spark Promotion Plan Project of Jiangxi Province [20188003]
  6. Health Development Planning Commission Science Foundation of Jiangxi Province [20201032, 202130210]
  7. Health Development Planning Commission Science TCM Foundation of Jiangxi Province [2018A060, 2020A0087]
  8. Education Department Foundation of Jiangxi Province [GJJ200157, GJJ200159, GJJ200169]

向作者/读者索取更多资源

This study investigated changes in functional connectivity (FC) in AMD patients using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed abnormalities in FC in several specific cerebral regions in AMD patients compared to healthy controls.
ObjectiveAge-related macular degeneration (AMD) causes visual damage and blindness globally. The purpose of this study was to investigate changes in functional connectivity (FC) in AMD patients using resting-state functional magnetic resonance imaging (rs-fMRI). Subjects and MethodsA total of 23 patients (12 male, 11 female) with AMD were enrolled to the AMD patients group (AMDs), and 17 healthy age-, sex-, and education-matched controls (9 male, 8 female) to the healthy controls group (HCs). All participants underwent rs-fMRI and mean FC values were compared between the two groups. ResultsSignificantly higher FC values were found in the inferior frontal gyrus (IFG), superior frontal gyrus (SFG), inferior parietal lobule (IPL), rectal gyrus (RTG), and superior parietal lobule (SPL) in AMDs compared with HCs. Conversely, FC values in the cerebellum posterior lobe (CPL), middle cingulate gyrus (MCG), medulla (MDL), cerebellum anterior lobe (CAL), and thalamus (TLM) were significantly lower in AMDs than in HCs. ConclusionThis study demonstrated FC abnormalities in many specific cerebral regions in AMD patients, and may provide new insights for exploration of potential pathophysiological mechanism of AMD-induced functional cerebral changes.

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