期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.830602
关键词
frontotemporal dementia with parkinsonism; prion protein gene; striatum; dopamine; positron emission tomography
资金
- National Natural Science Foundation of China [81971011, 81901285]
- Ministry of Science and Technology of China [2019YFC0118600]
- Beijing Municipal Science and Technology Committee [D171100008217005, 7202060]
- Beijing Postdoctoral Research Foundation [2020-ZZ-016]
This study investigates the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient with prion protein gene (PRNP) mutation. The findings suggest that the alteration of frontal striatal loops may be involved in cognitive impairment in FTDP, while the development of parkinsonism in FTDP may primarily be due to the involvement of the presynaptic nigrostriatal loops in PRNP V180I mutation.
ObjectiveTo explore the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient resulting from prion protein gene (PRNP) mutation. MethodsThis patient received clinical interviews and underwent neuropsychological assessments, genetic testing, [F-18]-fluorodeoxyglucose positron emission tomography ([F-18]-FDG PET)/MRI, and [F-18]-dihydrotetrabenazine positron emission tomography ([F-18]-DTBZ PET)/CT. Region-of-interest analysis was conducted concerning metabolism, and dopamine transport function between this patient and 12 controls, focusing on the striatum subregions according to the Oxford-GSK-Imanova Striatal Connectivity Atlas. ResultsA 64-year-old man initially presented with symptoms of motor dysfunction and subsequently behavioral and personality changes. FTDP was initially suspected. Sequence analysis disclosed a valine to isoleucine at codon 180 in PRNP. Compared to controls, this patient had a severe reduction (> 2SD) of standard uptake value ratio (SUVR) in the limbic and executive subregions but relative retention of metabolism in rostral motor and caudal motor subregions using [F-18]-FDG PET/MRI, and the SUVR decreased significantly across the striatal in [F-18]-DTBZ PET/CT, especially in the rostral motor and caudal motor subregions. ConclusionThe alteration of frontal striatal loops may be involved in cognitive impairment in FTDP, and the development of parkinsonism in FTDP may be primarily due to the involvement of the presynaptic nigrostriatal loops in PRNP V180I mutation.
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