期刊
CELL REPORTS
卷 39, 期 7, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2022.110815
关键词
-
类别
资金
- National Institutes of Health [DP5OD023056, T32AI060530, K23AI134327, T32GM007618, F30CA257291, P30DK063720, S10OD01 8040, S10OD021822]
- National Heart, Lung and Blood Institute of the Department of Health and Human Services [HHSN26820110001I]
This study used mass cytometry to characterize the longitudinal cellular immune response after acute Zika virus infection, finding that high frequencies of multiple activated cell types during acute infection were associated with high neutralizing antibody titers post-infection. In addition, stable immune features were associated with low antibody titers.
Although generating high neutralizing antibody levels is a key component of protective immunity after acute viral infection or vaccination, little is known about why some individuals generate high versus low neutralizing antibody titers. Here, we leverage the high-dimensional single-cell profiling capacity of mass cytometry to characterize the longitudinal cellular immune response to Zika virus (ZIKV) infection in viremic blood donors in Puerto Rico. During acute ZIKV infection, we identify widely coordinated responses across innate and adaptive immune cell lineages. High frequencies of multiple activated cell types during acute infection are associated with high titers of ZIKV neutralizing antibodies 6 months post-infection, while stable immune features suggesting a cytotoxic-skewed immune set point are associated with low titers. Our study offers insight into the coordination of immune responses and identifies candidate cellular biomarkers that may offer predictive value in vaccine efficacy trials aimed at inducing high levels of antiviral neutralizing antibodies.
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