期刊
CELL REPORTS
卷 39, 期 2, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2022.110669
关键词
-
类别
资金
- National Institute of Mental Health of the National Institutes of Health [R01 MH116675, R01 MH117996]
A comparison study between humans and non-hominoid primates reveals major differences in connectivity profiles of their DMNs. Non-hominoid primates show weaker correlated activity between mPFC and PCC compared to humans, where strong correlated activity between these two regions is a key feature of the human DMN.
The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate's DMN and its associated cognitive functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据