期刊
CELL REPORTS
卷 38, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2022.110398
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资金
- National Key Research and Development Program of the Ministry of Science and Technology of China [2018YFA0106901, 2018YFA0108101, 2021ZD0203802, 2017YFC0907503]
- National Natural Science Foundation of China [81827809, 81871898, 31701120, 31527802, 31871033]
- Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20180028]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB37000000]
- CAS Key Laboratory of Brain Connectome [2019DP173024]
- Chinese Academy of Sciences [QYZDY-SSW-SMC015]
Carip, a previously uncharacterized long non-coding RNA, regulates the phosphorylation of AMPA and NMDA receptor subunits through its interaction with CaMKIIb, thereby modulating long-term synaptic plasticity and spatial learning and memory in mice.
CaMKII has long been known to be a key effector for synaptic plasticity. Recent studies have shown that a variety of modulators interact with the subunits of CaMKII to regulate the long-term potentiation (LTP) of hippocampal neurons. However, whether long non-coding RNAs modulate the activity of CaMKII and affect synaptic plasticity is still elusive. Here, we identify a previously uncharacterized long non-coding RNA Carip that functions as a scaffold, specifically interacts with CaMKIIb, and regulates the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in the hippocampus. The absence of Carip causes dysfunction of synaptic transmission and attenuates LTP in hippocampal CA3-CA1 synapses, which further leads to impairment of spatial learning and memory. In summary, our findings demonstrate that Carip modulates long-term synaptic plasticity by changing AMPA receptor and NMDA receptor activities, thereby affecting spatial learning and memory in mice.
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