期刊
BMC PULMONARY MEDICINE
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12890-022-01868-5
关键词
Primary Sjogren syndrome; Interstitial lung disease; Warrick score; Risk factors; Raynaud's phenomenon
资金
- National Nature Science Foundation of China [81801630]
- National Nature Science Foundation of Hebei Province [H2018307047]
This study investigates the risk factors for interstitial lung disease (ILD) in patients with primary Sjogren's syndrome (pSS). The findings suggest that age, Raynaud's phenomenon, lymphopenia, cough, dyspnoea and rampant dental caries are associated with ILD in pSS patients. HRCT reveals common abnormalities, such as ground glass opacities and septal/sub pleural lines. It is important to systematically evaluate pSS patients with advanced age, dry cough and dyspnoea for ILD involvement.
Background Interstitial lung disease (ILD) may cause life-threatening complications of primary Sjogren's syndrome (pSS), and has a poor prognosis in terms of survival and quality of life. To date, few studies have investigated the risk factors for ILD detected by high-resolution computed tomography (HRCT) in pSS patients with or without respiratory symptoms. Methods Data of 333 patients with newly diagnosed pSS were retrospectively analysed. Interstitial lung disease involvement was defined as typical abnormalities on HRCT and/or pulmonary function tests. Multivariate regression model was used to evaluate the association between interstitial lung disease and pSS characteristics. Results Sixty-six patients (19.82%) were diagnosed with pSS-ILD. Ground glass opacities (87.88%) and septal/sub pleural lines (81.82%) were most frequent. Based on pulmonary high-resolution computed tomography, patients were divided into nonspecific (n = 42), usual (n = 20), lymphocytic interstitial pneumonia (n = 3) and cryptogenic organising pneumonia (n = 1) groups. There was a strong association between erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) and the HRCT-score. Pulmonary function tests revealed impaired diffusion capacity for carbon monoxide and total lung capacity, and coexistence of small airway lesions in pSS-interstitial lung disease. On logistic regression analysis, age, Raynaud's phenomenon, lymphopenia, cough, dyspnoea and rampant dental caries were risk factors associated with pSS-interstitial lung disease. Conclusions Interstitial lung disease involvement in pSS is a common clinical occurrence. The clinical manifestation is nonspecific and variable; Raynaud's phenomenon and lymphopenia may predict its onset. pSS patients with advanced age, dry cough and dyspnoea should be systematically evaluated for ILD involvement and managed according to their symptoms.
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