期刊
ANNALS OF LABORATORY MEDICINE
卷 42, 期 2, 页码 141-+出版社
KOREAN SOC LABORATORY MEDICINE
DOI: 10.3343/alm.2022.42.2.141
关键词
Key Words; Cell-free nucleic acid; Circulating tumor DNA; Pre-analytical phase; Epidermal growth factor receptor; Clinical practice guidelines
资金
- Research Fund of Quality Control Committee, Korean Society for Laboratory Medicine [2020-01-006]
- Korean Society for Genetic Diagnostics
Standardization of pre-analytical procedures is essential for obtaining clinically reliable results in cfDNA testing. This article provides evidence-based clinical practice guidelines for the pre-analytical phase procedures of plasma EGFR variant testing. By standardizing pre-analytical procedures, the analytical performance of cfDNA testing can be improved.
Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this re-view, we provide evidence-based clinical practice guidelines for pre-analytical phase pro-cedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.
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