期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 15, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202200467
关键词
hypoxia probes; J-aggregation; NIR-II phosphorescence; organometallic complexes
资金
- National Natural Science Foundation of China [61620106016, 61835009, 61775145, 62175161, 52073242, 51873176, 61975132]
- Shenzhen Basic Research Program [JCYJ20210324095810028]
- Hong Kong Research Grants Council [PolyU153058/19P]
- CAS-Croucher Funding Scheme for Joint Laboratories
- Guangdong-Hong Kong-Macao Joint Laboratory for Optoelectronic and Magnetic Functional Materials [2019B121205002]
- Hong Kong Polytechnic University [1-ZE1C]
- Research Institute for Smart Energy (RISE)
This study reports a new hypoxia probe PpyPt with NIR-II phosphorescence induced by J-aggregation. By constructing J-aggregates, water-soluble PpyPt nanoparticles (PpyPt NPs(4.76)) with good biological hypoxia sensing potential were successfully designed.
The luminescence of traditional phosphorescence-based hypoxia probes is limited to the visible and first near-infrared wavelength regions (<1000 nm), which has defects of higher light scattering and lower penetration depth in contrast with the second near-infrared wavelength window (NIR-II, 1000-1700 nm) for optical bioimaging. Herein, 5,15-bis(2,6-bis(dodecyloxy)phenyl)-porphyrin platinum(II) (PpyPt) with J-aggregation induced NIR-II phosphorescence is reported. J-aggregates of PpyPt are confirmed by the X-ray diffraction data in the crystalline state. Moreover, the emission and excitation spectra of PpyPt in the solid states reveal NIR-II luminescence feature of PpyPt in J-aggregates. More importantly, by preparation of water-soluble PpyPt nanoparticles (PpyPt NPs(4.76)) with J-aggregates, it has NIR-II phosphorescent lifetime of microseconds and good oxygen-sensitivity in water. Moreover, the good biological hypoxia-sensing potential of PpyPt NPs(4.76) is demonstrated in cells and 4T1-tumor-bearing mice. This study provides an efficient strategy to design NIR-II phosphorescent probe for sensitive tumor-hypoxia detection through the construction of J-aggregates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据