期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 14, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202200529
关键词
acid-responsive nanoporphyrin; structural evolution; NIR fluorescence; phototherapy; MRSA biofilms
资金
- National Natural Science Foundation of China [22078066]
- MPO [FV10599, FV30300]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2021R1A6A1A10039823, 2022R1A2C3005420]
- China Scholarship Council (CSC) [201904910820]
- Czech Academy of Sciences [VAJVA-19-48]
- European Regional Development Fund OP RDE (project ChemBioDrug) [CZ.02.1.01/0.0/0.0/16_019/0000729]
- Ministry of Education, Youth and Sports of the Czech Republic through the e-INFRA CZ [90140]
This study develops an acid-responsive nanoporphyrin for accurate diagnosis and treatment of biofilm infections, avoiding damage to normal tissue and offering a promising alternative to antibiotics.
Combating biofilm infections remains a challenge due to the shield and acidic conditions. Herein, an acid-responsive nanoporphyrin (PN3-NP) based on the self-assembly of a water-soluble porphyrin derivative (PN3) is constructed. Additional kinetic control sites formed by the conjugation of the spermine molecules to a porphyrin macrocycle make PN3 self-assemble into stable nanoparticles (PN3-NP) in the physiological environment. Noteworthily, near-infrared (NIR) fluorescence monitoring and synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) effects of PN3-NP can be triggered by the acidity in biofilms, accompanied by intelligent transformation into dot-like nanospheres. Thus, damage to normal tissue is effectively avoided and accurate diagnosis and treatment of biofilms is achieved successfully. The good results of fluorescence imaging-guided photo-ablation of antibiotic-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) biofilms verify that PN3-NP is a promising alternative to antibiotics. Meanwhile, this strategy also opens new horizons to engineer smart nano-photosensitizer for accurate diagnosis and treatment of biofilms.
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