4.7 Article

Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder

期刊

SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41598-022-11516-x

关键词

-

资金

  1. Wellcome Trust [103952/Z/14/Z, 212934/Z/18/Z]
  2. Croatian Science Foundation [IP-2016-06-8636]
  3. Wellcome Trust [212934/Z/18/Z] Funding Source: Wellcome Trust

向作者/读者索取更多资源

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of alpha-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据