期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-11623-9
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资金
- AstraZeneca, US Government [W15QKN-20-9-1003]
Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222 vaccination. A study analyzed anti-PF4 levels in paired samples from a phase 3 trial of AZD1222 vs placebo. The results indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
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