期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-08283-0
关键词
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资金
- Ministry of Education, Science, Technology, Sports and Culture of Japan [19H03333, 20J14621, JP16H06280]
- Grants-in-Aid for Scientific Research [20J14621, 19H03333] Funding Source: KAKEN
Developmental maturation in larval zebrafish is associated with slow swimming behavior, particularly in older larvae who can maintain head stability during slow swimming. The MCoD neurons play a role in coordinating trunk muscle activities to produce the stable head and S-shaped swimming form. The ablation of MCoD neurons results in a change in swimming form and increased yaw displacement of the head.
Developmental maturation occurs in slow swimming behavior in larval zebrafish; older larvae acquire the ability to perform slow swimming while keeping their head stable in the yaw dimension. A class of long-distance descending commissural excitatory V0v neurons, called MCoD neurons, are known to develop in a later phase of neurogenesis, and participate in slow swimming in older larvae. We hypothesized that these MCoD neurons play a role in coordinating the activities of trunk muscles in the diagonal dimension (e.g., the rostral left and the caudal right) to produce the S-shaped swimming form that contributes to the stability of the head. Here, we show that MCoD neurons do indeed play this role. In larvae in which MCoD neurons were laser-ablated, the swimming body form often adopted a one-sided (C-shaped) bend with reduced appearance of the normal S-shaped bend. With this change in swimming form, the MCoD-ablated larvae exhibited a greater degree of head yaw displacement during slow swimming. In mice, the long-distance descending commissural V0v neurons have been implicated in diagonal interlimb coordination during walking. Together with this, our study suggests that the long-distance descending commissural V0v neurons form an evolutionarily conserved pathway in the spinal locomotor circuits that coordinates the movements of the diagonal body/limb muscles.
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