期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-12289-z
关键词
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资金
- NIH/NINDS [R41 RNS112029A]
- NRF/MSIT [2020R1F1A1A0107244511]
This paper presents a novel method for measuring the permittivity of two-dimensional anisotropic tissues using a multi-electrode cross-shaped needle. By designing a new needle and analyzing the apparent impedance, the authors propose three methods to estimate the anisotropic muscle permittivity. This research opens up new possibilities for neuromuscular diagnosis and assessing the effects of therapeutic interventions on muscle health.
Application of minimally invasive methods to enable the measurement of tissue permittivity in the neuromuscular clinic remain elusive. This paper provides a theoretical and modeling study on the measurement of the permittivity of two-dimensional anisotropic tissues such as skeletal muscle with a multi-electrode cross-shaped needle. For this, we design a novel cross-shaped needle with multiple-electrodes and analyse apparent impedance corresponding to the measured impedance. In addition, we propose three methods of estimate anisotropic muscle permittivity. Compared to existing electrical impedance-based needle methods that we have developed, the new needle design and numerical methods associated enable estimating in vivo muscle permittivity values with only a single needle insertion. Being able to measure muscle permittivity directly with a single needle insertion could open up an entirely new area of research with direct clinical application, including using these values to assist in neuromuscular diagnosis and to assess subtle effects of therapeutic intervention on muscle health.
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