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Letter
Medicine, General & Internal
A. David Paltiel et al.
ANNALS OF INTERNAL MEDICINE
(2021)
Letter
Medicine, General & Internal
Ashleigh R. Tuite et al.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Health Care Sciences & Services
A. David Paltiel et al.
Summary: Implementation factors play a crucial role in the success of vaccination programs, outweighing vaccine efficacy determined in clinical trials. Manufacturing or deployment delays, vaccine hesitancy, and increased epidemic severity can significantly diminish the benefits of a vaccine.
Article
Multidisciplinary Sciences
Kate M. Bubar et al.
Summary: The study found that prioritizing the vaccine for adults aged 20 to 49 can minimize the number of cases, while prioritizing the vaccine for adults over 60 can minimize mortality and years of life lost. Redirecting vaccine doses to seronegative individuals through individual-level serological tests can improve the impact of each dose.
Article
Medicine, General & Internal
Sara Y. Tartof et al.
Summary: This study aimed to assess the overall and variant-specific effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19-related hospital admissions among members of a healthcare system in California. The effectiveness of the vaccine remained high against hospital admissions even up to 6 months after full vaccination, despite a decline in effectiveness against SARS-CoV-2 infections over time, which was likely due to waning immunity rather than the delta variant escaping vaccine protection.
Article
Medicine, General & Internal
Yair Goldberg et al.
Summary: The immunity against the delta variant of SARS-CoV-2 waned in all age groups in Israel a few months after receiving the second dose of the vaccine, leading to an increase in infection and severe cases.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Noa Dagan et al.
Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Eric J. Haas et al.
Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.
Article
Medicine, General & Internal
Victoria Jane Hall et al.
Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.
Article
Infectious Diseases
Sam Moore et al.
Summary: The study found that vaccination alone is insufficient to contain the outbreak. Even with an optimistic assumption that the vaccine can prevent 85% of infections, the reproduction number (R) is estimated to be 1.58 once all eligible adults have been offered both doses of the vaccine without non-pharmaceutical interventions (NPIs).
LANCET INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Giulia Giordano et al.
Summary: This study combines multiple models to predict the spread and consequences of COVID-19 cases, finding that non-pharmaceutical interventions have a greater impact on the epidemic evolution. Using a data-based model, different scenarios of vaccine rollouts and interventions are proposed to assess their impact on the pandemic.
Article
Biochemical Research Methods
Sam Moore et al.
Summary: The COVID-19 outbreak has shown the vulnerability to novel infections and the UK, like many other countries, enforced social distancing measures to reduce transmission. Vaccination is seen as the only way to contain the infection and return to normalcy, with targeting older age groups first being considered optimal. This vaccination strategy is crucial in reducing mortality and healthcare demands, but success is dependent on vaccine characteristics and population uptake.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Mathematical & Computational Biology
Marcos Amaku et al.
Summary: The study presents a new mathematical model to estimate the impact of vaccination delay against COVID-19 in Brazil, showing that delays in vaccination schedules can lead to significant increases in mortality. The authors emphasize the importance of speeding up the vaccination process to reach the highest number of immunized people in the shortest period of time to reduce deaths.
THEORETICAL BIOLOGY AND MEDICAL MODELLING
(2021)
Review
Ecology
Katalin Csillery et al.
TRENDS IN ECOLOGY & EVOLUTION
(2010)
Article
Multidisciplinary Sciences
Tina Toni et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2009)
