Evaluation of efficiency and sensitivity of 1D and 2D sample pooling strategies for SARS-CoV-2 RT-qPCR screening purposes

Letter Infectious Diseases

Ct values from SARS-CoV-2 diagnostic PCR assays should not be used as direct estimates of viral load

Elias Dahdouh et al.

JOURNAL OF INFECTION (2021)

Article Cell Biology

Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settings

Brian Cleary et al.

Summary: Virological testing is crucial for containing SARS-CoV-2, but many settings face severe limitations on testing. Researchers found that using group testing designs can effectively increase testing throughput and maximize the number of detected infections under various resource constraints, thus enhancing surveillance capabilities in resource-limited settings.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests

Netta Barak et al.

Summary: Pooling multiple swab samples for SARS-CoV-2 testing can save 76% of RNA extraction and RT-PCR tests, with higher efficiency and sensitivity than expected, even in populations with varying prevalence rates.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Engineering, Electrical & Electronic

A Compressed Sensing Approach to Pooled RT-PCR Testing for COVID-19 Detection

Sabyasachi Ghosh et al.

Summary: The Tapestry method proposed is a single-round pooled testing method that combines compressed sensing and combinatorial group testing ideas, allowing for shorter testing time and conservation of resources in COVID-19 testing. It can achieve significant resource savings at low prevalence rates and high feasibility at high prevalence rates.

IEEE OPEN JOURNAL OF SIGNAL PROCESSING (2021)

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Article Pathology