Immunogenicity of ChAdOx1 nCoV-19 vaccine after a two-dose inactivated SARS-CoV-2 vaccination of dialysis patients and kidney transplant recipients

Article Urology & Nephrology

SARS-CoV-2 Antibody Response After a Third Dose of the BNT162b2 Vaccine in Patients Receiving Maintenance Hemodialysis or Peritoneal Dialysis

Ilias Bensouna et al.

Summary: The effectiveness of a third dose of the BNT162b2 vaccine in patients undergoing dialysis treatment was investigated, and it was found that the third dose significantly increased antibody levels.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

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Article Surgery

Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients

Marta Kantauskaite et al.

Summary: Kidney transplant recipients (KTRs) have a weaker immune response to SARS-CoV-2 vaccination compared to controls, with mycophenolate mofetil (MMF) treatment being the strongest predictor for impaired response. Adjusting MMF dose may improve the immune response in KTRs.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Review Immunology

COVID-19 in Immunocompromised Hosts: What We Know So Far

Monica Fung et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant morbidity and mortality globally. The impact of the disease on immunosuppressed patients, such as cancer patients and transplant recipients, remains unclear. Further research is needed to determine the risk of COVID-19 severity and death in immunocompromised patients.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

A case of successful treatment of severe COVID-19 pneumonia with favipiravir and tocilizumab in post-kidney transplant recipient

Theerachai Thammathiwat et al.

Summary: A case of COVID-19 in a kidney transplant patient in Thailand is reported. The patient's symptoms improved after receiving high-flow nasal cannula oxygen therapy and antiviral treatment, but reversible acute kidney injury occurred due to drug interaction between tacrolimus and antiviral treatment.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.

CELL (2021)

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Letter Medicine, General & Internal

responses to SARS-CoV-2 vaccines in kidney transplant recipients

Maria Prendecki et al.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Shuo Feng et al.

Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.

NATURE MEDICINE (2021)

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Editorial Material Urology & Nephrology

COVID-19 vaccination in kidney transplant recipients

Sophie Caillard et al.

Summary: Kidney transplant recipients, due to therapeutic immunosuppression, have impaired immune responses to the COVID-19 mRNA vaccine, necessitating a personalized intensified vaccination approach for better protection.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Immunology

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

Jianmin Zuo et al.

Summary: The study shows that functional SARS-CoV-2-specific T cell responses are retained and robust at 6 months following infection, with higher T cell responses observed in donors who had experienced symptomatic infection. Levels of nucleoprotein-specific T cells were correlated with nucleoprotein-specific antibody levels, providing insights into the persistence and correlation of immune responses.

NATURE IMMUNOLOGY (2021)

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Article Immunology

Antibody response to two doses of inactivated SARS-CoV-2 vaccine (CoronaVac) in kidney transplant recipients

Rezzan Eren Sadioglu et al.

Summary: This study found that the antibody response to the inactivated vaccine was considerably low (18.8%) in kidney transplant recipients. Increased age and impaired renal function were associated with a worse antibody response. Due to the knowledge that mRNA vaccines yield better humoral responses, this special population might be considered for additional doses of mRNA vaccination.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Letter Medicine, General & Internal

Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Medicine, General & Internal

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Immunology

Longitudinal Humoral Responses after COVID-19 Vaccination in Peritoneal and Hemodialysis Patients over Twelve Weeks

Claudius Speer et al.

Summary: Patients undergoing hemo- or peritoneal dialysis show lower levels of antibodies after vaccination compared to healthy individuals, with a significant decrease observed after the second dose. Boosters may be necessary for high-risk individuals with impaired seroconversion or declining neutralizing antibody levels.

VACCINES (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Safety and Immunogenicity of Anti-SARS-CoV-2 Messenger RNA Vaccines in Recipients of Solid Organ Transplants

Olivier Marion et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Letter Urology & Nephrology

Humoral response after 3 doses of the BNT162b2 mRNA COVID-19 vaccine in patients on hemodialysis

Didier Ducloux et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Risk factors associated with poor response to COVID-19 vaccination in kidney transplant recipients

Yorg Azzi et al.

KIDNEY INTERNATIONAL (2021)

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Letter Medicine, General & Internal

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Edward J. Carr et al.

LANCET (2021)

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Letter Medicine, General & Internal

Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

Nassim Kamar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Immunology

COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions

Wajihul Hasan Khan et al.

Summary: COVID-19 is caused by the SARS-CoV-2 virus originating from Wuhan City, China, leading to a global pandemic that has resulted in millions of deaths. Various vaccine candidates are in development to combat new variants, but face challenges in effectiveness.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Urology & Nephrology

Humoral response to a third injection of BNT162b2 vaccine in patients on maintenance haemodialysis

Marine Dekervel et al.

Summary: The study revealed that a third dose of BNT162b2 vaccine enhanced the humoral response against SARS-CoV-2 in maintenance dialysis patients, leading to seroconversion in more non-responders.

CLINICAL KIDNEY JOURNAL (2021)

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Article Transplantation

COVID-19 vaccination in haemodialysis patients: good things come in threes...

Luc Frantzen et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Immunology

Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG

Sina Schwarzkopf et al.

Summary: The study found that in convalescent patients, immunity against SARS-CoV-2 may be mediated through T cells even in the absence of detectable IgG antibodies.

EMERGING INFECTIOUS DISEASES (2021)

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Article Immunology