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The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases

NUTRIENTS (2022)

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Summary: Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and is associated with liver diseases. Dysregulated metabolic pathways and impaired iron homeostasis play a role in the progression of liver disease via ferroptosis. Several ferroptosis-associated genes and pathways have been implicated in liver disease. Targeting ferroptosis may have therapeutic potential for managing liver diseases.

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Summary: A nanocarrier material based on angelica polysaccharide was synthesized to target liver cancer in a hypoxic microenvironment and selectively enhance ferroptosis in solid tumors. The amphiphilic polymer micelles AAAF were confirmed to release drugs in response to hypoxia, showing potential for sensitizing ferroptosis and anti-tumor effects.

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Lipopolysaccharide-induced splenic ferroptosis in goslings was alleviated by polysaccharide of atractylodes macrocephala koidz associated with proinflammatory factors

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Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

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A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways

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Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO

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Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response-induced upregulation of CHAC1 expression

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A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo

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