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Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis

NUTRIENTS (2022)

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Review Endocrinology & Metabolism

Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis

R. Pal et al.

Summary: The study found that vitamin D supplementation may be associated with improved clinical outcomes in COVID-19 patients, especially when administered post-diagnosis. However, questions regarding the appropriate dose, duration, and mode of administration of vitamin D remain unanswered and require further research.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Article Medicine, General & Internal

Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)

Ashu Rastogi et al.

Summary: This study investigates the effect of high-dose oral cholecalciferol supplementation on SARS-CoV-2 viral clearance. The results show that supplementation with cholecalciferol can increase the proportion of vitamin D-deficient individuals who become SARS-CoV-2 RNA negative and reduce fibrinogen levels.

POSTGRADUATE MEDICAL JOURNAL (2022)

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Review Food Science & Technology

Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis

Marcos Pereira et al.

Summary: This systematic review and meta-analysis found that vitamin D deficiency is associated with a higher prevalence in severe cases of COVID-19. Vitamin D insufficiency is also linked to increased hospitalization and mortality from COVID-19.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Endocrinology & Metabolism

Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis

Dimple Rawat et al.

Summary: A meta-analysis showed that vitamin-D supplementation did not significantly improve mortality, ICU admission rates, or need for invasive ventilation in COVID-19 patients. Further well-designed RCTs are needed to address this topic.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Article Medicine, General & Internal

Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis

K. Shah et al.

Summary: The meta-analysis suggests that vitamin D supplementation may reduce ICU requirement in hospitalized COVID-19 patients, but has comparable effect on mortality when compared to placebo treatment. More robust data from randomized controlled trials are needed to further evaluate its effects.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Article Nutrition & Dietetics

Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study

Sandro Giannini et al.

Summary: This retrospective study aimed to examine the clinical outcome of hospitalized COVID-19 patients receiving high-dose cholecalciferol treatment. The study found that the therapeutic effect of vitamin D treatment on COVID-19 patients may be significantly impacted by the burden of comorbidities.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank

Hao Ma et al.

Summary: The habitual use of vitamin D supplements is associated with a lower risk of COVID-19 infection, with no significant association found between circulating or genetically predicted vitamin D levels and the risk of infection. Further clinical trials are needed to confirm these results and rule out potential confounding factors.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

Cedric Annweiler et al.

Summary: The study found that supplementation of vitamin D3 prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19. The intervention group had a significantly higher survival rate at 3 months compared to the comparator group, with a lower hazard ratio for 3-month mortality.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Medicine, General & Internal

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial

Igor H. Murai et al.

Summary: The study found that a single high dose of vitamin D-3 did not significantly reduce hospital length of stay among hospitalized patients with COVID-19. The findings do not support the use of a high dose of vitamin D-3 for treatment of moderate to severe COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Nutrition & Dietetics

Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy

Emanuele Cereda et al.

NUTRITION (2021)

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Article Endocrinology & Metabolism

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

David A. Jolliffe et al.

Summary: Vitamin D supplementation was found to be safe and reduce the risk of acute respiratory infections, especially when administered in daily doses of 400-1000 IU for up to 12 months and to participants aged 1.00-15.99 years. However, the relevance of these findings to COVID-19 is uncertain and further investigation is needed.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

Joaquim Oristrell et al.

Summary: The study suggests that calcitriol supplementation may benefit patients with advanced chronic kidney disease in reducing the risk of infection, severe illness, and mortality during the COVID-19 pandemic.

BIOMEDICINES (2021)

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Article Nutrition & Dietetics

The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study

Mehmet Guven et al.

Summary: This study aimed to investigate the relationship between clinical course and inhospital mortality with high-dose vitamin D-3 administration within the first 24 hours of admission for COVID-19 ICU patients with vitamin D deficiency. The results showed that parenteral administration of high-dose vitamin D-3 did not reduce the need for intubation, length of hospital stay, and inhospital mortality in critically ill COVID-19 patients with vitamin D deficiency.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Calcifediol Treatment and COVID-19-Related Outcomes

Xavier Nogues et al.

Summary: The study aimed to elucidate the effect of calcifediol treatment on COVID-19 outcomes. The findings showed that in hospitalized patients with COVID-19, calcifediol treatment significantly reduced ICU admission and mortality.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Nutrition & Dietetics

Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study

Juan F. Alcala-Diaz et al.

Summary: A study in five hospitals in the South of Spain found that COVID-19 patients who received oral calcifediol treatment had significantly lower in-hospital mortality during the first 30 days compared to those who did not receive the treatment.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

Shaun Sabico et al.

Summary: The study demonstrated that daily supplementation of 5000 IU vitamin D3 for two weeks significantly increased serum 25(OH)D levels. Additionally, the 5000 IU group had a shorter recovery time for cough and loss of taste compared to the 1000 IU group.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

被撤回的出版物: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease (Retracted article. See vol. 12, 2022)

Maheshwar Lakkireddy et al.

Summary: This study investigated the impact of Pulse D therapy on reducing inflammatory markers of COVID-19. The results showed a significant reduction in inflammatory markers in the VD group after receiving Pulse D therapy, while the reduction in the NVD group was not significant.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Guillaume Butler-Laporte et al.

Summary: This study utilized Mendelian randomization to investigate the relationship between increased vitamin D levels and COVID-19 outcomes. The results consistently showed no evidence supporting an association between genetically predicted vitamin D levels and COVID-19 susceptibility, severity, or hospitalization. Other therapeutic or preventative avenues should be prioritized for COVID-19 randomized controlled trials based on these findings.

PLOS MEDICINE (2021)

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Article Medicine, General & Internal

Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation

Gabriela Athziri Sanchez-Zuno et al.

Summary: The study found that vitamin D deficiency in COVID-19 outpatients is associated with disease severity, and vitamin D supplementation can alleviate symptoms and increase serum concentrations.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

Alberto Caballero-Garcia et al.

Summary: Vitamin D supplementation may reduce indicators of muscle damage in elderly COVID-19 patients during the recovery phase, potentially contributing to improvements in their health status and quality of life.

MEDICINA-LITHUANIA (2021)

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Review Pharmacology & Pharmacy

The Impact of Vitamin D Supplementation on Mortality Rate and Clinical Outcomes of COVID-19 Patients: A Systematic Review and Meta-Analysis

Leila Nikniaz et al.

Summary: Vitamin D supplementation has a positive impact on COVID-19 patients, reducing mortality rate, severity of the disease, and levels of inflammatory markers. Further research is needed to determine the optimal type, dosage, and duration of supplementation.

PHARMACEUTICAL SCIENCES (2021)

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Article Medicine, General & Internal

COVID-19 severity in relation to sociodemographics and vitamin D use

Darya Saeed Abdulateef et al.

Summary: This study aimed to evaluate the severity of COVID-19, and found that stress, age, and presence of comorbidities were significant positive predictors of severity, while prophylactic vitamin D use and smoking were significant negative predictors. Additionally, the use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.

OPEN MEDICINE (2021)

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Article Endocrinology & Metabolism

Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection

Jose L. Hernandez et al.

Summary: The study found that hospitalized COVID-19 patients have significantly lower serum 25OHD levels than population-based controls, and the prevalence of vitamin D deficiency is higher in COVID-19 patients. However, no relationship was found between vitamin D concentrations or deficiency and the severity of the disease at this time.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Vitamin D and survival in COVID-19 patients: A quasi-experimental study

Cedric Annweiler et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study

Marta Entrenas Castillo et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

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Article Medicine, General & Internal

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

David O. Meltzer et al.

JAMA NETWORK OPEN (2020)

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Article Cell Biology

Mortality in an italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests

Biagio Cangiano et al.

Aging-US (2020)

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Article Nutrition & Dietetics

High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study

Stephanie F. Ling et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study

Gaelle Annweiler et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Effect of Vitamin D Supplementation on the Level of Circulating High-Sensitivity C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

Neng Chen et al.

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Review Health Care Sciences & Services

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2009)

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