4.7 Article

TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects

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Summary: Past research has found distinct phenotypic differences in responses to sweet taste, but the origins of these differences are still unclear. One possibility is that the individual differences in sweet liking are a manifestation of differences in sensitivity to the bitter tastant PROP, which is also related to differences in food liking and preference. However, previous studies on the relationship between sweet liking and PROP tasting have had mixed results. This could be due to older studies using a more simplistic characterization of sweet likers, while recent research suggests three different sweet liking phenotypes. Overall, the data suggest that PROP tasting and sweet liking are not causally related, but the sweet dislikers phenotype may be partly explained by a broader tendency for anhedonia.

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