Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse

Article Public, Environmental & Occupational Health

Alcohol Consumption and Binge Drinking During Pregnancy Among Adults Aged 18–49 Years — United States, 2018–2020

Lucas K. Gosdin et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

Article Nutrition & Dietetics

Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

Nipun Saini et al.

Summary: Prenatal alcohol exposure can cause fetal growth restrictions. Alcohol affects maternal metabolism, limiting glucose availability and resulting in changes in metabolic products, which may impact fetal weight.

NUTRIENTS (2022)

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Article Substance Abuse

Growth and behavioral differences in a C57BL/6J mouse model of prenatal alcohol exposure

Sandra M. Mooney et al.

Summary: Through prenatal alcohol exposure in mice, the study found that it can lead to behavioral deficits without causing growth or morphological deficits. This mouse model shows characteristics related to ARND in terms of behavior.

ALCOHOL (2021)

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Article Substance Abuse

Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs

Sze Ting (Cecilia) Kwan et al.

Summary: Choline supplementation during pregnancy can help prevent a reduction in gestational weight gain and fetal body weight after alcohol exposure, as well as correct fetal brain sparing. However, choline does not normalize fetal liver growth in alcohol-exposed offspring.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2021)

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Article Substance Abuse

Alterations in Insulin Levels in Adults with Prenatal Alcohol Exposure

Julie A. Kable et al.

Summary: The study found that prenatal alcohol exposure could impact insulin production and signaling, leading to different insulin levels between PAE individuals and Controls with normal BMI. However, the rate of insulin increase relative to BMI was higher in PAE individuals, indicating potential differential impact on diabetes disease and cognitive impairment.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2021)

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Article Multidisciplinary Sciences

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

Manjot S. Virdee et al.

Summary: Prenatal alcohol exposure (PAE) leads to permanent cognitive disabilities, while microbial-dependent products (MDPs) generated by the enteric microbiome may be associated with disorders such as autism, depression, and anxiety. Analysis of a mouse model showed that alcohol exposure altered the levels of MDPs in maternal and fetal plasma, potentially influencing pathologies related to PAE.

SCIENTIFIC REPORTS (2021)

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Article Endocrinology & Metabolism

The effect of heavy prenatal alcohol exposure on adolescent body mass index and waist-to-height ratio at 12-13 years

N. Hayes et al.

Summary: Heavy prenatal alcohol exposure may have a gender-specific effect on measures of adiposity in adolescents, with females more likely to have increased BMI and overweight/obesity status. Further longitudinal follow-up of children exposed to PAE is needed to confirm if maternal alcohol consumption is a risk factor for later-life obesity.

INTERNATIONAL JOURNAL OF OBESITY (2021)

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Article Medicine, Research & Experimental

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

Olivia Weeks et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Substance Abuse

Adverse Health Outcomes in Offspring Associated With Fetal Alcohol Exposure: A Systematic Review of Clinical and Preclinical Studies With a Focus on Metabolic and Body Composition Outcomes

Lisa K. Akison et al.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2019)

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Review Allergy

Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune-related outcomes

Natasha Reid et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2019)

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Article Neurosciences

Metabolic Syndrome and Cognitive Trajectories in the Framingham Offspring Study

Katherine J. Bangen et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Neurosciences

Prenatal alcohol exposure programmes offspring disease: insulin resistance in adult males in a rat model of acute exposure

Tam M. T. Nguyen et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

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Article Medicine, General & Internal

Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities

Philip A. May et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Review Endocrinology & Metabolism

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

Freddy J. Alfaro et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

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Article Multidisciplinary Sciences

Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder

Robyn M. Amos-Kroohs et al.

PLOS ONE (2018)

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Review Immunology

Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function

Shahani Noor et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Endocrinology & Metabolism

Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring

Emelie M. Gardebjer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2018)

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Review Biochemistry & Molecular Biology

Key proteins and pathways that regulate lifespan

Haihui Pan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Neurosciences

Maternal alcohol binge drinking induces persistent neuroinflammation associated with myelin damage and behavioural dysfunctions in offspring mice

Lidia Cantacorps et al.

NEUROPHARMACOLOGY (2017)

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Article Neurosciences

Effects of prenatal alcohol exposure in a prospective sample of young adults: Mental health, substance use, and difficulties with the legal system

Mary Ellen Lynch et al.

NEUROTOXICOLOGY AND TERATOLOGY (2017)

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Article Clinical Neurology

Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

Rebecca F. Gottesman et al.

JAMA NEUROLOGY (2017)

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Article Psychiatry

Quantitative neurobiological evidence for accelerated brain aging in alcohol dependence

Matthias Guggenmos et al.

TRANSLATIONAL PSYCHIATRY (2017)

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Review Substance Abuse

Alcohol-Induced Developmental Origins of Adult-Onset Diseases

Emilie R. Lunde et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)

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Article Immunology

Evidence for an immune signature of prenatal alcohol exposure in female rats

Tamara S. Bodnar et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Article Pediatrics

Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder

Robyn M. Amos-Kroohs et al.

JOURNAL OF PEDIATRICS (2016)

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Review Neurosciences

Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations

Jean N. Cheong et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

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Article Pediatrics

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders

H. Eugene Hoyme et al.

PEDIATRICS (2016)

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Article Pediatrics

Fetal Alcohol Growth Restriction and Cognitive Impairment

R. Colin Carter et al.

PEDIATRICS (2016)

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Article Biochemistry & Molecular Biology

Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high-fat diet

Emelie M. Gardebjer et al.

FASEB JOURNAL (2015)

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Article Substance Abuse

Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure

Rachel L. Werts et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)

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Article Substance Abuse

Overweight and Obesity Among Children and Adolescents with Fetal Alcohol Spectrum Disorders

Anita J. Fuglestad et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)

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Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

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Article Multidisciplinary Sciences

Impact of Low Dose Prenatal Ethanol Exposure on Glucose Homeostasis in Sprague-Dawley Rats Aged up to Eight Months

Megan E. Probyn et al.

PLOS ONE (2013)

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Review Developmental Biology

Sex differences in developmental programming models

Catherine E. Aiken et al.

REPRODUCTION (2013)

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Article Endocrinology & Metabolism

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring

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NUTRITION & DIABETES (2012)

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Review Cell Biology

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

Vincenza Frisardi et al.

AGEING RESEARCH REVIEWS (2010)

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Review Neurosciences

Metabolic Syndrome and Cognitive Impairment: Current Epidemiology and Possible Underlying Mechanisms

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JOURNAL OF ALZHEIMERS DISEASE (2010)

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Article Genetics & Heredity

Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model

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Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse

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