期刊
NUTRIENTS
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu14091828
关键词
curcumin; gut microbiota; cholesterol absorption; cholesterol supersaturation; gallstones
资金
- National Natural Science Foundation of China [81973019]
- Natural Science Foundation of Guangdong Province [2022A1515011610, 2020A1515011167, 2018A030313782]
- Guangdong Medical Science and Technology Research Fund Project [A2018482, A2019127]
This study found that curcumin reduces cholesterol levels and bile cholesterol supersaturation by modulating gut microbiota and inhibiting intestinal cholesterol absorption.
Curcumin is a polyphenol that has been shown to have prebiotic and cholesterol-lowering properties. This study aimed to investigate the impact of curcumin on bile cholesterol supersaturation and the potential mechanistic role of intestinal microbiota and cholesterol absorption. Male hamsters (n = 8) were fed a high-fat diet (HFD) supplemented with or without curcumin for 12 weeks. Results showed that curcumin significantly decreased cholesterol levels in the serum (from 5.10 to 4.10 mmol/L) and liver (from 64.60 to 47.72 nmol/mg protein) in HFD-fed hamsters and reduced the bile cholesterol saturation index (CSI) from 1.64 to 1.08 due to the beneficial modifications in the concentration of total bile acids (BAs), phospholipids and cholesterol (p < 0.05). Gut microbiota analysis via 16S rRNA sequencing revealed that curcumin modulated gut microbiota, predominantly increasing microbiota associated with BA metabolism and short-chain fatty acid production, which subsequently up-regulated the expression of hepatic cholesterol 7-alpha hydroxylase and increased the synthesis of bile acids (p < 0.05). Furthermore, curcumin significantly down-regulated the expression of intestinal Niemann-Pick C1-like protein 1(NPC1L1) in hamsters and reduced cholesterol absorption in Caco-2 cells (p < 0.05). Our results demonstrate that dietary curcumin has the potential to prevent bile cholesterol supersaturation through modulating the gut microbiota and inhibiting intestinal cholesterol absorption.
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