期刊
NUTRIENTS
卷 14, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nu14112277
关键词
leptin; celastrol; perinatal nutrition; metabolically obese; normal weight
资金
- MCIN/AEI por FEDER Una manera de hacer Europa [PGC2018-097436-B-I00]
- Spanish Government
Perinatal administration of leptin provides protection against the consequences of dietary imbalances leading to metabolically obese, normal-weight (MONW) phenotype, while celastrol treatment does not provide the same protective effect and may even have negative effects on adipose tissue. Co-administration of leptin improves the negative effects of celastrol on adipose tissue.
Perinatal nutrition has a well-known influence on obesity susceptibility. We previously demonstrated the protective anti-obesity effects of perinatal leptin administration. Celastrol is a natural compound acting as a leptin sensitizer with anti-obesity effects when administered in adult animals. Here, we aimed to determine if perinatal treatment with leptin, celastrol, or their combination was able to improve metabolic health in animals fed an isocaloric high-fat (HF) diet. Leptin and/or celastrol or their vehicle were administered orally to rats during the suckling period. After weaning, animals were chronically pair-fed with an HF diet provided isocaloric to the intake of a normal-fat diet by control animals to avoid obesity. Isocaloric HF feeding in vehicle-treated animals resulted in metabolic features characteristic of the metabolically obese, normal-weight (MONW) phenotype, i.e., obesity-related disturbances without increased body weight. Leptin treatment prevented liver fat deposition and insulin resistance, induced greater insulin and leptin signaling capacity, decreased gene expression of orexigenic signals at the hypothalamic level, and induced browning in retroperitoneal adipose tissue. However, celastrol treatment did not provide any protective effect and resulted in greater size of the retroperitoneal adipose depot, higher circulating glucose and insulin levels, and decreased leptin sensitivity capacity in adipose tissue. The co-administration of leptin ameliorated the negative effects of celastrol on the retroperitoneal depot, inducing browning and decreasing its size. In conclusion, the perinatal administration of leptin, but not celastrol, provided protection against the consequences of dietary unbalances leading to an MONW phenotype in adulthood.
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