Intestinal 'Infant-Type' Bifidobacteria Mediate Immune System Development in the First 1000 Days of Life

Immune system maturation begins early in life, but few studies have examined how early-life gut microbiota colonization educates the neonatal immune system. Bifidobacteria predominate in the intestines of breastfed infants and metabolize human milk oligosaccharides. This glycolytic activity alters the intestinal microenvironment and consequently stimulates immune system maturation at the neonatal stage. However, few studies have provided mechanistic insights into the contribution of 'infant-type' Bifidobacterium species, especially via metabolites such as short-chain fatty acids. In this review, we highlight the first 1000 days of life, which provide a window of opportunity for infant-type bifidobacteria to educate the neonatal immune system. Furthermore, we discuss the instrumental role of infant-type bifidobacteria in the education of the neonatal immune system by inducing immune tolerance and suppressing intestinal inflammation, and the potential underlying mechanism of this immune effect in the first 1000 days of life. We also summarize recent research that suggests the administration of infant-type bifidobacteria helps to modify the intestinal microecology and prevent the progress of immune-mediated disorders.

Automated summary

This review discusses the role of gut microbiota in educating the neonatal immune system, focusing on the importance of infant-type bifidobacteria during the first 1000 days of life. It highlights the immune tolerance and intestinal inflammation suppression induced by infant-type bifidobacteria, as well as the potential underlying mechanisms. Recent research suggesting the administration of infant-type bifidobacteria for modifying the intestinal microecology and preventing immune-mediated disorders is also summarized.