期刊
NUTRIENTS
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nu14102105
关键词
malnutrition; nutritional risk; critical care; acute respiratory distress syndrome; COVID-19; mortality; intensive care
This study evaluated the effectiveness of four nutritional risk assessment tools and explored the predictive value of CT-derived fat tissue and muscle mass measurements in predicting in-hospital mortality of critically ill patients with COVID-19-associated ARDS. The results showed that the nutritional risk assessment tools can accurately predict mortality, while fat tissue and muscle mass were not associated with increased mortality risk.
Background: Malnutrition predicts a worse outcome for critically ill patients. However, quick, easy-to-use nutritional risk assessment tools have not been adequately validated. Aims and Methods: The study aimed to evaluate the role of four biological nutritional risk assessment instruments (the Prognostic Nutritional Index-PNI, the Controlling Nutritional Status Score-CONUT, the Nutrition Risk in Critically Ill-NUTRIC, and the modified NUTRIC-mNUTRIC), along with CT-derived fat tissue and muscle mass measurements in predicting in-hospital mortality in a consecutive series of 90 patients hospitalized in the intensive care unit for COVID-19-associated ARDS. Results: In-hospital mortality was 46.7% (n = 42/90). Non-survivors had a significantly higher nutritional risk, as expressed by all four scores. All scores were independent predictors of mortality on the multivariate regression models. PNI had the best discriminative capabilities for mortality, with an area under the curve (AUC) of 0.77 for a cut-off value of 28.05. All scores had an AUC above 0.72. The volume of fat tissue and muscle mass were not associated with increased mortality risk. Conclusions: PNI, CONUT, NUTRIC, and mNUTRIC are valuable nutritional risk assessment tools that can accurately predict mortality in critically ill patients with COVID-19-associated ARDS.
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