期刊
NUTRIENTS
卷 14, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nu14081621
关键词
gestational hypertension; anemia; birth cohort; children; infant
资金
- National Natural Science Foundation of China [81903327, 82173527]
- Beijing Natural Science Foundation [7194285]
- National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) [BYSYSZKF2021001]
- Incubation Program of China and Peking University Health Science Center [BMU2017YB003]
- Young Elite Scientist Sponsorship Program by CAST (YESS) [2018QNRC001]
- US Centers for Disease Control and Prevention [U01 DD000293]
- Peking University [U01 DD000293]
The study found that gestational hypertension may increase the risk of childhood anemia, and similar conclusions were drawn from two Chinese birth cohorts.
Gestational hypertension may interfere with the placental iron metabolism, thus probably increasing the risk of childhood anemia. We aim to examine the association between gestational hypertension and childhood anemia at different ages in two large Chinese birth cohorts. Cohort 1 was conducted in 5 counties in northern China and was comprised of 17,264 mother-children pairs (97.3%) during 2006-2009, whereas cohort 2 was conducted in 21 counties in southern China and was comprised of 185,093 mother-children pairs (93.8%) during 1993-1996. All pregnant women were registered in a monitoring system and followed up until the termination of pregnancies. The childhood anemia was diagnosed at 6 month and 12 month in cohort 1 and at 55 month in cohort 2. The overall incidence of childhood anemia was 6.78% and 5.28% at 6 month and 12 month, respectively, in cohort 1 and 13.18% at 55 month in cohort 2. Gestational hypertension was associated with increased risk of anemia at 6 month (adjusted Odds Ratio (OR): 1.31; 95% confidence interval (CI): 1.05, 1.63) and at 12 month (adjusted OR: 1.50; 95% CI: 1.18, 1.90) in cohort 1 and at 55 month (adjusted OR: 1.06; 95% CI: 1.01, 1.12) in cohort 2. The hemoglobin values of children at different ages were lower among gestational hypertension group in the linear models, which was consistent with the results of binary regression analysis. Our study found gestational hypertension may associate with an increased risk of childhood anemia. It suggests a possible need for exploring changes in prenatal care that might prevent childhood anemia.
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