4.7 Article

Plasma Retinoid Concentrations Are Altered in Pregnant Women

期刊

NUTRIENTS
卷 14, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/nu14071365

关键词

vitamin A; retinoid; pregnancy; postpartum; retinol-binding protein 4 (RBP4); transthyretin (TTR)

资金

  1. National Institute of General Medical Sciences [R01GM124264]

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This study aims to investigate the changes in maternal vitamin A levels during pregnancy. The findings reveal that plasma retinol concentrations are lower, but all-trans-retinoic acid concentrations are higher during pregnancy.
Vitamin A is vital to maternal-fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women (n = 23) during two stages of pregnancy (25-28 weeks gestation and 28-32 weeks gestation) as compared to >= 3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25-28 weeks gestation, plasma retinol (-27%), 4-oxo-13-cis-retinoic acid (-34%), and albumin (-22%) concentrations were significantly lower, and all-trans-retinoic acid (+48%) concentrations were significantly higher compared to >= 3 months postpartum in healthy women. In addition, at 28-32 weeks gestation, plasma retinol (-41%), retinol binding protein 4 (RBP4; -17%), transthyretin (TTR; -21%), albumin (-26%), 13-cis-retinoic acid (-23%) and 4-oxo-13-cis-retinoic acid (-48%) concentrations were significantly lower, whereas plasma all-trans-retinoic acid concentrations (+30%) were significantly higher than >= 3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but all-trans-retinoic acid concentrations are higher than postpartum.

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